Assay Detail
Binding
CHEMBL760597
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Phosphodiesterase-4A (PDE4)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
3',5'-cyclic-AMP phosphodiesterase 4A (CHEMBL254) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Substituted 2-pyridinemethanol derivatives as potent and selective phosphodiesterase-4 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.32 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL57524 | — | — | 1 | 9.00 |
| CHEMBL32442 | CDP840 | — | 1 | 8.40 |
| CHEMBL56330 | — | — | 1 | 8.22 |
| CHEMBL57095 | — | — | 1 | 7.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL57524 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL32442 | CDP840 | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL56330 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL57095 | — | IC50 | = | 23.0 | nM | 7.64 |