Assay Detail
Functional
CHEMBL760642
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Concentration required to inhibit PAF-induced maximum aggregation
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
[(3-Pyridylalkyl)piperidylidene]benzocycloheptapyridine derivatives as dual antagonists of PAF and histamine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 5.23 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL91261 | — | — | 1 | 6.66 |
| CHEMBL88343 | — | — | 1 | 6.14 |
| CHEMBL10971 | SCH-37370 | — | 1 | 6.08 |
| CHEMBL90398 | — | — | 1 | 5.82 |
| CHEMBL423316 | — | — | 1 | 5.75 |
| CHEMBL329826 | — | — | 1 | 5.51 |
| CHEMBL90194 | — | — | 1 | 5.47 |
| CHEMBL91397 | RUPATADINE | 4.0 | 1 | 5.43 |
| CHEMBL90893 | — | — | 1 | 5.40 |
| CHEMBL90668 | — | — | 1 | 5.22 |
| CHEMBL539286 | — | — | 1 | 5.09 |
| CHEMBL544552 | — | — | 1 | 5.05 |
| CHEMBL91729 | — | — | 1 | 4.89 |
| CHEMBL90299 | — | — | 1 | 4.85 |
| CHEMBL91565 | — | — | 1 | 4.82 |
| CHEMBL433006 | — | — | 1 | 4.77 |
| CHEMBL327230 | — | — | 1 | 4.70 |
| CHEMBL544551 | — | — | 1 | 4.47 |
| CHEMBL420809 | — | — | 1 | 4.43 |
| CHEMBL92108 | — | — | 1 | 4.07 |
| CHEMBL998 | LORATADINE | 4.0 | 1 | - |
| CHEMBL329547 | — | — | 1 | - |
| CHEMBL91486 | — | — | 1 | - |
| CHEMBL91455 | — | — | 1 | - |
| CHEMBL329390 | — | — | 1 | - |
| CHEMBL555304 | — | — | 1 | - |
| CHEMBL329451 | — | — | 1 | - |
| CHEMBL329370 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL91261 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL88343 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL10971 | SCH-37370 | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL90398 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL423316 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL329826 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL90194 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL91397 | RUPATADINE | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL90893 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL90668 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL539286 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL544552 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL91729 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL90299 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL91565 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL433006 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL327230 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL544551 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL420809 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL92108 | — | IC50 | = | 85000.0 | nM | 4.07 |
| CHEMBL998 | LORATADINE | IC50 | = | 135000.0 | nM | - |
| CHEMBL329547 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL91486 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL91455 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL329390 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL555304 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL329451 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL329370 | — | IC50 | > | 100000.0 | nM | - |