Assay Detail
Binding
CHEMBL761279
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against mouse PDGF beta receptor tyrosine kinase
47
Total Activities
47
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Platelet-derived growth factor receptor beta (CHEMBL2749) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Synthesis and structure-activity relationships of 7-substituted 3-(2, 6-dichlorophenyl)-1,6-naphthyridin-2(1H)-ones as selective inhibitors of pp60(c-src).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 47 | 5.85 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL49120 | PD-0166285 | 1.0 | 1 | 7.10 |
| CHEMBL107277 | — | — | 1 | 7.00 |
| CHEMBL104779 | — | — | 1 | 7.00 |
| CHEMBL51283 | — | — | 1 | 6.96 |
| CHEMBL104414 | — | — | 1 | 6.58 |
| CHEMBL110403 | — | — | 1 | 6.58 |
| CHEMBL104357 | — | — | 1 | 6.54 |
| CHEMBL107458 | — | — | 1 | 6.44 |
| CHEMBL301612 | — | — | 1 | 6.40 |
| CHEMBL106772 | — | — | 1 | 6.19 |
| CHEMBL104153 | — | — | 1 | 6.17 |
| CHEMBL106232 | — | — | 1 | 6.15 |
| CHEMBL107423 | — | — | 1 | 6.13 |
| CHEMBL419914 | — | — | 1 | 6.10 |
| CHEMBL104244 | — | — | 1 | 6.05 |
| CHEMBL104071 | — | — | 1 | 6.05 |
| CHEMBL104322 | — | — | 1 | 5.96 |
| CHEMBL108333 | — | — | 1 | 5.96 |
| CHEMBL323453 | — | — | 1 | 5.85 |
| CHEMBL104304 | — | — | 1 | 5.85 |
| CHEMBL107676 | — | — | 1 | 5.62 |
| CHEMBL299194 | — | — | 1 | 5.55 |
| CHEMBL106992 | — | — | 1 | 5.55 |
| CHEMBL108013 | — | — | 1 | 5.55 |
| CHEMBL320382 | — | — | 1 | 5.51 |
| CHEMBL106953 | — | — | 1 | 5.50 |
| CHEMBL108004 | — | — | 1 | 5.44 |
| CHEMBL420477 | — | — | 1 | 5.34 |
| CHEMBL49596 | — | — | 1 | 5.31 |
| CHEMBL106295 | — | — | 1 | 5.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL49120 | PD-0166285 | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL107277 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL104779 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL51283 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL104414 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL110403 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL104357 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL107458 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL301612 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL106772 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL104153 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL106232 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL107423 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL419914 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL104071 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL104244 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL104322 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL108333 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL323453 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL104304 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL107676 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL108013 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL299194 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL106992 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL320382 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL106953 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL108004 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL420477 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL49596 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL106295 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL107472 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL318519 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL48172 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL106839 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL107071 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL50470 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL108332 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL322005 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL107418 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL108170 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL107177 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL420473 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL104532 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL106379 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL107247 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL107372 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL323017 | — | IC50 | > | 50000.0 | nM | - |