Assay Detail
Binding
CHEMBL761405
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Binding affinity against cloned human oxytocin receptor from human embryonic kidney cells
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | kidney |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Nonpeptide oxytocin antagonists: potent, orally bioavailable analogs of L-371,257 containing a 1-R-(pyridyl)ethyl ether terminus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 7.51 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL104237 | — | — | 1 | 8.70 |
| CHEMBL322187 | — | — | 1 | 8.41 |
| CHEMBL105406 | — | — | 1 | 8.27 |
| CHEMBL105514 | — | — | 1 | 8.13 |
| CHEMBL102994 | — | — | 1 | 8.10 |
| CHEMBL24781 | — | — | 1 | 8.03 |
| CHEMBL104530 | — | — | 1 | 7.82 |
| CHEMBL105039 | — | — | 1 | 7.77 |
| CHEMBL318174 | — | — | 1 | 7.27 |
| CHEMBL102762 | — | — | 1 | 7.24 |
| CHEMBL105960 | — | — | 1 | 7.14 |
| CHEMBL319646 | — | — | 1 | 7.14 |
| CHEMBL27157 | — | — | 1 | 7.06 |
| CHEMBL105673 | — | — | 1 | 6.80 |
| CHEMBL105733 | — | — | 1 | 6.58 |
| CHEMBL322162 | — | — | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL104237 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL322187 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL105406 | — | Ki | = | 5.4 | nM | 8.27 |
| CHEMBL105514 | — | Ki | = | 7.34 | nM | 8.13 |
| CHEMBL102994 | — | Ki | = | 7.9 | nM | 8.10 |
| CHEMBL24781 | — | Ki | = | 9.3 | nM | 8.03 |
| CHEMBL104530 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL105039 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL318174 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL102762 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL105960 | — | Ki | = | 73.0 | nM | 7.14 |
| CHEMBL319646 | — | Ki | = | 73.0 | nM | 7.14 |
| CHEMBL27157 | — | Ki | = | 87.0 | nM | 7.06 |
| CHEMBL105673 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL105733 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL322162 | — | Ki | = | 1800.0 | nM | 5.75 |