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Compound Detail

CHEMBL319646

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COc1cc(OCc2ccccc2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1

Basic Information

ChEMBL ID CHEMBL319646
Phase Preclinical
Structure Type MOL
InChI Key BOJYCDRNXGUATP-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

472.5
MW (Da)
5.04
ALogP
5
HBA
0
HBD
68.3
PSA (Ų)
0.50
QED
1
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C28H28N2O5
MW 472.54
Aromatic Rings 3
Heavy Atoms 35
NP-Likeness -0.69

Activity Summary

Ki 1 meas. best 7.14

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Oxytocin receptor
CHEMBL2049
Ki 7.14 7.14 73.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Oxytocin receptor Ki = 73.0 nM 7.14 Binding affinity against cloned human oxytocin receptor from human embryonic kid... 9873680

Literature References

PubMed DOI Target Context # Activities
9873680 10.1016/s0960-894x(98)00568-x Oxytocin receptor 1

Data from ChEMBL 36 via Core Engine