Assay Detail
Functional
CHEMBL761492
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Compound was evaluated for the ability to inhibit CCK-stimulated amylase release in pancreatic acinar cells of guinea pig
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Hybrid cholecystokinin (CCK) antagonists: new implications in the design and modification of CCK antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.74 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL112307 | — | — | 1 | 7.80 |
| CHEMBL112222 | — | — | 1 | 7.44 |
| CHEMBL114325 | AMIGLUMIDE | 2.0 | 1 | 7.44 |
| CHEMBL349857 | — | — | 1 | 7.19 |
| CHEMBL115269 | — | — | 1 | 6.96 |
| CHEMBL9485 | — | — | 1 | 6.75 |
| CHEMBL112215 | — | — | 1 | 6.55 |
| CHEMBL158362 | — | — | 1 | 6.23 |
| CHEMBL349640 | — | — | 1 | 6.08 |
| CHEMBL162111 | — | — | 1 | 4.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL112307 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL112222 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL114325 | AMIGLUMIDE | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL349857 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL115269 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL9485 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL112215 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL158362 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL349640 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL162111 | — | IC50 | = | 11000.0 | nM | 4.96 |