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Assay Detail

CHEMBL761741

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Functional
In vitro inhibitory activity on platelet aggregation induced by arachidonic acid (AA)
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Confidence 1 — Organism
Curated By Intermediate

Target

Homo sapiens (CHEMBL372)
Type ORGANISM
Organism Homo sapiens

Publication

Synthesis of 4-alkoxy-2-phenylquinoline derivatives as potent antiplatelet agents.
Ko TC, Hour MJ, Lien JC, Teng CM, Lee KH, Kuo SC, Huang LJ.
Bioorg Med Chem Lett (2001) 11 : 279 -282
PubMed 11212091 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 5.83 7.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL322169 1 7.10
CHEMBL96056 1 6.85
CHEMBL6 INDOMETHACIN 4.0 1 6.60
CHEMBL318419 1 6.28
CHEMBL330375 1 6.22
CHEMBL95158 1 6.11
CHEMBL316657 1 5.81
CHEMBL96449 1 5.73
CHEMBL15527 1 5.70
CHEMBL279335 1 5.67
CHEMBL329347 1 5.40
CHEMBL94795 1 4.86
CHEMBL25 ASPIRIN 4.0 1 4.70
CHEMBL93842 1 4.52
CHEMBL321047 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL322169 IC50 = 80.0 nM 7.10
CHEMBL96056 IC50 = 140.0 nM 6.85
CHEMBL6 INDOMETHACIN IC50 = 250.0 nM 6.60
CHEMBL318419 IC50 = 530.0 nM 6.28
CHEMBL330375 IC50 = 600.0 nM 6.22
CHEMBL95158 IC50 = 780.0 nM 6.11
CHEMBL316657 IC50 = 1540.0 nM 5.81
CHEMBL96449 IC50 = 1880.0 nM 5.73
CHEMBL15527 IC50 = 2010.0 nM 5.70
CHEMBL279335 IC50 = 2130.0 nM 5.67
CHEMBL329347 IC50 = 3970.0 nM 5.40
CHEMBL94795 IC50 = 13880.0 nM 4.86
CHEMBL25 ASPIRIN IC50 = 20000.0 nM 4.70
CHEMBL93842 IC50 = 30040.0 nM 4.52
CHEMBL321047 IC50 = 218300.0 nM -