Assay Detail
Binding
CHEMBL761833
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory activity against bovine phosphodiesterase 5
33
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
cGMP-specific 3',5'-cyclic phosphodiesterase (CHEMBL3478) ↗| Type | SINGLE PROTEIN |
| Organism | Bos taurus |
Publication
The discovery of tadalafil: a novel and highly selective PDE5 inhibitor. 2: 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 7.72 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL138466 | — | — | 2 | 8.52 |
| CHEMBL342459 | — | — | 1 | 8.52 |
| CHEMBL343553 | — | — | 1 | 8.30 |
| CHEMBL343941 | — | — | 1 | 8.30 |
| CHEMBL779 | TADALAFIL | 4.0 | 2 | 8.30 |
| CHEMBL138504 | — | — | 1 | 8.30 |
| CHEMBL141307 | — | — | 1 | 8.22 |
| CHEMBL140599 | — | — | 1 | 8.22 |
| CHEMBL434797 | — | — | 2 | 8.22 |
| CHEMBL139771 | — | — | 1 | 8.10 |
| CHEMBL336716 | — | — | 1 | 8.05 |
| CHEMBL142143 | — | — | 1 | 8.00 |
| CHEMBL342008 | NORTADALAFIL | — | 2 | 7.96 |
| CHEMBL142138 | — | — | 1 | 7.82 |
| CHEMBL141703 | — | — | 1 | 7.77 |
| CHEMBL445576 | — | — | 1 | 7.75 |
| CHEMBL436019 | — | — | 1 | 7.64 |
| CHEMBL139597 | — | — | 1 | 7.58 |
| CHEMBL334684 | — | — | 1 | 7.39 |
| CHEMBL342876 | — | — | 1 | 7.22 |
| CHEMBL141518 | — | — | 1 | 7.22 |
| CHEMBL343325 | — | — | 1 | 7.16 |
| CHEMBL139028 | — | — | 1 | 7.05 |
| CHEMBL344700 | — | — | 1 | 7.04 |
| CHEMBL2111963 | — | — | 1 | 6.86 |
| CHEMBL336050 | — | — | 1 | 6.12 |
| CHEMBL139521 | — | — | 1 | 5.22 |
| CHEMBL344855 | — | — | 1 | - |
| CHEMBL341939 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL138466 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL342459 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL779 | TADALAFIL | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL138466 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL779 | TADALAFIL | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL343553 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL138504 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL343941 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL141307 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL140599 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL434797 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL139771 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL434797 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL336716 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL142143 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL342008 | NORTADALAFIL | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL342008 | NORTADALAFIL | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL142138 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL141703 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL445576 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL436019 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL139597 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL334684 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL342876 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL141518 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL343325 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL139028 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL344700 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL2111963 | — | IC50 | = | 138.0 | nM | 6.86 |
| CHEMBL336050 | — | IC50 | = | 758.0 | nM | 6.12 |
| CHEMBL139521 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL344855 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL341939 | — | IC50 | > | 10000.0 | nM | - |