Compound Detail
CHEMBL342008
NORTADALAFIL Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL342008 |
| Name | NORTADALAFIL |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XHDLVMPUSXRZOS-FOIQADDNSA-N |
2
Targets
4
Activities
2
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
375.4
MW (Da)
1.87
ALogP
4
HBA
2
HBD
83.7
PSA (Ų)
0.68
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 6.52
IC50 2 meas. best 7.96
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| cGMP-specific 3',5'-cyclic phosphodiesterase CHEMBL3478 | IC50 | 7.96 | 7.94 | 11.0 | 2 |
| Rattus norvegicus CHEMBL376 | EC50 | 6.52 | 6.37 | 300.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| cGMP-specific 3',5'-cyclic phosphodiesterase | IC50 | = | 11.0 | nM | 7.96 | In vitro inhibitory activity against bovine phosphodiesterase 5 | 14521415 |
| cGMP-specific 3',5'-cyclic phosphodiesterase | IC50 | = | 12.0 | nM | 7.92 | In vitro inhibitory activity against bovine phosphodiesterase 5 | 14521415 |
| Rattus norvegicus | EC50 | = | 300.0 | nM | 6.52 | Effective concentration against rat aortic smooth muscle cell | 14521415 |
| Rattus norvegicus | EC50 | = | 600.0 | nM | 6.22 | Effective concentration against rat aortic smooth muscle cell | 14521415 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 14521415 | 10.1021/jm0300577 | cGMP-specific 3',5'-cyclic phosphodiesterase | 2 |
| 14521415 | 10.1021/jm0300577 | Rattus norvegicus | 2 |
| 21504142 | 10.1021/jm1014617 | Plasmodium falciparum | 1 |
| 21504142 | 10.1021/jm1014617 | MRC5 | 1 |
Data from ChEMBL 36 via Core Engine