Assay Detail
Functional
CHEMBL779967
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration against rat aortic smooth muscle cell
27
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
The discovery of tadalafil: a novel and highly selective PDE5 inhibitor. 2: 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 27 | 6.25 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL779 | TADALAFIL | 4.0 | 2 | 6.82 |
| CHEMBL434797 | — | — | 2 | 6.82 |
| CHEMBL141703 | — | — | 1 | 6.70 |
| CHEMBL334684 | — | — | 1 | 6.70 |
| CHEMBL343941 | — | — | 1 | 6.52 |
| CHEMBL342008 | NORTADALAFIL | — | 2 | 6.52 |
| CHEMBL139597 | — | — | 1 | 6.46 |
| CHEMBL336716 | — | — | 1 | 6.30 |
| CHEMBL141307 | — | — | 1 | 6.30 |
| CHEMBL138466 | — | — | 2 | 6.22 |
| CHEMBL436019 | — | — | 1 | 6.22 |
| CHEMBL342459 | — | — | 1 | 6.10 |
| CHEMBL142143 | — | — | 1 | 6.00 |
| CHEMBL138504 | — | — | 1 | 6.00 |
| CHEMBL343553 | — | — | 1 | 5.82 |
| CHEMBL140599 | — | — | 1 | 5.52 |
| CHEMBL2111963 | — | — | 1 | 5.46 |
| CHEMBL342876 | — | — | 1 | - |
| CHEMBL445576 | — | — | 1 | - |
| CHEMBL142138 | — | — | 1 | - |
| CHEMBL344700 | — | — | 1 | - |
| CHEMBL141518 | — | — | 1 | - |
| CHEMBL343325 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL434797 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL779 | TADALAFIL | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL334684 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL141703 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL342008 | NORTADALAFIL | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL343941 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL139597 | — | EC50 | = | 350.0 | nM | 6.46 |
| CHEMBL336716 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL141307 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL779 | TADALAFIL | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL434797 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL342008 | NORTADALAFIL | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL138466 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL436019 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL342459 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL138466 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL142143 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL138504 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL343553 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL140599 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL2111963 | — | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL445576 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL142138 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL342876 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL344700 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL141518 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL343325 | — | EC50 | > | 10000.0 | nM | - |