Compound Detail
CHEMBL138504
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Basic Information
| ChEMBL ID | CHEMBL138504 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XWBJKKIHTRCECR-UHFFFAOYSA-N |
3
Targets
3
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
403.5
MW (Da)
4.25
ALogP
3
HBA
1
HBD
65.6
PSA (Ų)
0.65
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.52
EC50 1 meas. best 6.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| cGMP-specific 3',5'-cyclic phosphodiesterase CHEMBL1827 | IC50 | 8.52 | 8.52 | 3.0 | 1 |
| cGMP-specific 3',5'-cyclic phosphodiesterase CHEMBL3478 | IC50 | 8.3 | 8.3 | 5.0 | 1 |
| Rattus norvegicus CHEMBL376 | EC50 | 6.0 | 6.0 | 1000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| cGMP-specific 3',5'-cyclic phosphodiesterase | IC50 | = | 3.0 | nM | 8.52 | Inhibition of PDE5 (unknown origin) | 33528252 |
| cGMP-specific 3',5'-cyclic phosphodiesterase | IC50 | = | 5.0 | nM | 8.3 | In vitro inhibitory activity against bovine phosphodiesterase 5 | 14521415 |
| Rattus norvegicus | EC50 | = | 1000.0 | nM | 6.0 | Effective concentration against rat aortic smooth muscle cell | 14521415 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 14521415 | 10.1021/jm0300577 | cGMP-specific 3',5'-cyclic phosphodiesterase | 1 |
| 14521415 | 10.1021/jm0300577 | Rattus norvegicus | 1 |
| 33528252 | 10.1021/acs.jmedchem.0c01887 | cGMP-specific 3',5'-cyclic phosphodiesterase | 1 |
Data from ChEMBL 36 via Core Engine