Assay Detail
Binding
CHEMBL762090
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Binding affinity for rat oxytocin receptor (OT-R)
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Development of orally active oxytocin antagonists: studies on 1-(1-[4-[1-(2-methyl-1-oxidopyridin-3-ylmethyl)piperidin-4-yloxy]-2- methoxybenzoyl]piperidin-4-yl)-1,4-dihydrobenz[d][1,3]oxazin-2-one (L-372,662) and related pyridines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 27 | 7.86 | 8.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL303700 | — | — | 1 | 8.49 |
| CHEMBL66985 | — | — | 1 | 8.47 |
| CHEMBL308673 | — | — | 1 | 8.39 |
| CHEMBL302297 | — | — | 1 | 8.37 |
| CHEMBL306416 | — | — | 1 | 8.29 |
| CHEMBL66992 | — | — | 1 | 8.11 |
| CHEMBL68480 | — | — | 1 | 8.10 |
| CHEMBL69202 | — | — | 1 | 8.07 |
| CHEMBL68800 | — | — | 1 | 8.07 |
| CHEMBL66240 | — | — | 1 | 7.96 |
| CHEMBL303487 | — | — | 1 | 7.92 |
| CHEMBL306010 | — | — | 1 | 7.92 |
| CHEMBL71540 | — | — | 1 | 7.89 |
| CHEMBL65950 | — | — | 1 | 7.85 |
| CHEMBL306645 | — | — | 1 | 7.82 |
| CHEMBL265070 | — | — | 1 | 7.80 |
| CHEMBL69265 | — | — | 1 | 7.80 |
| CHEMBL69201 | — | — | 1 | 7.70 |
| CHEMBL69520 | — | — | 1 | 7.60 |
| CHEMBL65949 | — | — | 1 | 7.57 |
| CHEMBL68914 | — | — | 1 | 7.55 |
| CHEMBL69539 | — | — | 1 | 7.54 |
| CHEMBL68978 | — | — | 1 | 7.54 |
| CHEMBL68199 | — | — | 1 | 7.52 |
| CHEMBL66567 | — | — | 1 | 7.44 |
| CHEMBL66749 | — | — | 1 | 7.28 |
| CHEMBL304577 | — | — | 1 | 7.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL303700 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL66985 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL308673 | — | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL302297 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL306416 | — | Ki | = | 5.1 | nM | 8.29 |
| CHEMBL66992 | — | Ki | = | 7.7 | nM | 8.11 |
| CHEMBL68480 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL69202 | — | Ki | = | 8.5 | nM | 8.07 |
| CHEMBL68800 | — | Ki | = | 8.5 | nM | 8.07 |
| CHEMBL66240 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL303487 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL306010 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL71540 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL65950 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL306645 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL265070 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL69265 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL69201 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL69520 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL65949 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL68914 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL69539 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL68978 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL68199 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL66567 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL66749 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL304577 | — | Ki | = | 65.0 | nM | 7.19 |