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Compound Detail

CHEMBL66749

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COc1cc(OC2CCN(C(C)c3cccnc3)CC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1

Basic Information

ChEMBL ID CHEMBL66749
Phase Preclinical
Structure Type MOL
InChI Key KCFRZWANFUYIQH-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

570.7
MW (Da)
5.46
ALogP
7
HBA
0
HBD
84.4
PSA (Ų)
0.37
QED
2
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C33H38N4O5
MW 570.69
Aromatic Rings 3
Heavy Atoms 42
NP-Likeness -0.85

Activity Summary

Ki 2 meas. best 7.8

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Oxytocin receptor
CHEMBL2049
Ki 7.8 7.8 16.0 1
Oxytocin receptor
CHEMBL3996
Ki 7.28 7.28 53.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
9622556 10.1021/jm9800797 Oxytocin receptor 2

Data from ChEMBL 36 via Core Engine