Assay Detail
Binding
CHEMBL762236
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Binding affinity for cloned human oxytocin receptor (OT-R)
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Development of orally active oxytocin antagonists: studies on 1-(1-[4-[1-(2-methyl-1-oxidopyridin-3-ylmethyl)piperidin-4-yloxy]-2- methoxybenzoyl]piperidin-4-yl)-1,4-dihydrobenz[d][1,3]oxazin-2-one (L-372,662) and related pyridines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 36 | 8.38 | 9.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL66985 | — | — | 1 | 9.09 |
| CHEMBL303700 | — | — | 1 | 9.09 |
| CHEMBL302297 | — | — | 1 | 9.00 |
| CHEMBL308673 | — | — | 1 | 9.00 |
| CHEMBL306416 | — | — | 1 | 8.96 |
| CHEMBL71540 | — | — | 1 | 8.92 |
| CHEMBL66931 | — | — | 1 | 8.85 |
| CHEMBL68480 | — | — | 1 | 8.82 |
| CHEMBL68800 | — | — | 1 | 8.77 |
| CHEMBL66992 | — | — | 1 | 8.70 |
| CHEMBL66240 | — | — | 1 | 8.68 |
| CHEMBL265070 | — | — | 1 | 8.64 |
| CHEMBL302128 | — | — | 1 | 8.64 |
| CHEMBL69202 | — | — | 1 | 8.60 |
| CHEMBL302029 | — | — | 1 | 8.60 |
| CHEMBL68816 | — | — | 1 | 8.48 |
| CHEMBL303487 | — | — | 1 | 8.46 |
| CHEMBL306645 | — | — | 1 | 8.39 |
| CHEMBL306010 | — | — | 1 | 8.38 |
| CHEMBL24781 | — | — | 1 | 8.32 |
| CHEMBL308460 | — | — | 1 | 8.32 |
| CHEMBL68199 | — | — | 1 | 8.29 |
| CHEMBL65949 | — | — | 1 | 8.28 |
| CHEMBL65950 | — | — | 1 | 8.25 |
| CHEMBL69265 | — | — | 1 | 8.17 |
| CHEMBL69201 | — | — | 1 | 8.15 |
| CHEMBL68978 | — | — | 1 | 8.11 |
| CHEMBL68914 | — | — | 1 | 8.00 |
| CHEMBL69539 | — | — | 1 | 7.96 |
| CHEMBL69520 | — | — | 1 | 7.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL66985 | — | Ki | = | 0.81 | nM | 9.09 |
| CHEMBL303700 | — | Ki | = | 0.82 | nM | 9.09 |
| CHEMBL308673 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL302297 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL306416 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL71540 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL66931 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL68480 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL68800 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL66992 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL66240 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL265070 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL302128 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL69202 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL302029 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL68816 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL303487 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL306645 | — | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL306010 | — | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL308460 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL24781 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL68199 | — | Ki | = | 5.1 | nM | 8.29 |
| CHEMBL65949 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL65950 | — | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL69265 | — | Ki | = | 6.7 | nM | 8.17 |
| CHEMBL69201 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL68978 | — | Ki | = | 7.8 | nM | 8.11 |
| CHEMBL68914 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL69539 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL69520 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL68752 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL68373 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL66749 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL66567 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL304577 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL69498 | — | Ki | = | 82.0 | nM | 7.09 |