Assay Detail
Functional
CHEMBL762567
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Relaxing effect determined by measuring inhibition of acetylcholine-induced contractions in pig coronary arteries.
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Sus scrofa |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
3-Methyl-2H-1-benzopyran potassium channel activators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 6.24 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL106121 | — | — | 1 | 8.40 |
| CHEMBL104552 | — | — | 1 | 8.22 |
| CHEMBL108107 | — | — | 1 | 8.15 |
| CHEMBL322249 | — | — | 1 | 7.70 |
| CHEMBL317641 | — | — | 1 | 7.70 |
| CHEMBL316977 | — | — | 1 | 7.70 |
| CHEMBL318737 | — | — | 1 | 7.52 |
| CHEMBL327249 | — | — | 1 | 7.30 |
| CHEMBL12552 | BIMAKALIM | 2.0 | 1 | 7.30 |
| CHEMBL318520 | EMAKALIM | 2.0 | 1 | 6.52 |
| CHEMBL266381 | — | — | 1 | 6.16 |
| CHEMBL49035 | CROMAKALIM | 2.0 | 1 | 6.16 |
| CHEMBL106594 | — | — | 1 | 5.40 |
| CHEMBL325775 | — | — | 1 | 5.30 |
| CHEMBL105481 | — | — | 1 | 5.22 |
| CHEMBL105852 | — | — | 1 | 4.70 |
| CHEMBL106390 | — | — | 1 | 4.70 |
| CHEMBL106179 | — | — | 1 | 4.40 |
| CHEMBL106600 | — | — | 1 | 4.30 |
| CHEMBL320905 | — | — | 1 | 4.10 |
| CHEMBL104635 | — | — | 1 | 4.00 |
| CHEMBL406508 | — | — | 1 | - |
| CHEMBL105038 | — | — | 1 | - |
| CHEMBL319428 | — | — | 1 | - |
| CHEMBL102475 | — | — | 1 | - |
| CHEMBL104860 | — | — | 1 | - |
| CHEMBL106122 | — | — | 1 | - |
| CHEMBL105799 | — | — | 1 | - |
| CHEMBL101688 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL106121 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL104552 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL108107 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL322249 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL317641 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL316977 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL318737 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL327249 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL12552 | BIMAKALIM | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL318520 | EMAKALIM | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL266381 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL49035 | CROMAKALIM | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL106594 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL325775 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL105481 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL105852 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL106390 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL106179 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL106600 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL320905 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL104635 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL406508 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL105038 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL319428 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL102475 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL104860 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL106122 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL105799 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL101688 | — | IC50 | > | 100000.0 | nM | - |