Compound Detail
CHEMBL12552
BIMAKALIM 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL12552 |
| Name | BIMAKALIM |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | JTVSKASWNROQQF-UHFFFAOYSA-N |
4
Targets
8
Activities
3
Assay Types
0
PK Parameters
13
Publications
1
Known Names
Molecular Properties
278.3
MW (Da)
2.78
ALogP
4
HBA
0
HBD
55.0
PSA (Ų)
0.81
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Activity Summary
EC50 4 meas. best 7.79
IC50 3 meas. best 7.3
Ki 1 meas.
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Rattus norvegicus CHEMBL376 | EC50 | 7.79 | 7.37 | 16.2 | 3 |
| Oryctolagus cuniculus CHEMBL374 | EC50 | 7.57 | 7.57 | 27.0 | 1 |
| Sus scrofa CHEMBL613488 | IC50 | 7.3 | 7.3 | 50.0 | 1 |
| Oryctolagus cuniculus CHEMBL374 | IC50 | 7.24 | 7.24 | 57.0 | 1 |
| Cavia porcellus CHEMBL369 | IC50 | 7.05 | 7.05 | 89.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Rattus norvegicus | EC50 | = | 16.22 | nM | 7.79 | Dilator activity expressed as potency for relaxation of Aortic rings precontract... | 11855989 |
| Oryctolagus cuniculus | EC50 | = | 27.0 | nM | 7.57 | Drug concentration required to induce half maximal hyperpolarization in rabbit m... | 1920358 |
| Rattus norvegicus | EC50 | = | 30.2 | nM | 7.52 | Negative logarithm of the molar concentration required to relax rat aorta precon... | - |
| Sus scrofa | IC50 | = | 50.0 | nM | 7.3 | Relaxing effect determined by measuring inhibition of acetylcholine-induced cont... | 1920358 |
| Oryctolagus cuniculus | IC50 | = | 57.0 | nM | 7.24 | Relaxing effect by measuring inhibition of noradrenaline-induced contractions in... | 1920358 |
| Cavia porcellus | IC50 | = | 89.0 | nM | 7.05 | Inhibition of spontaneous tone in Guinea pig tracheal spiral strips. | 2231602 |
| Rattus norvegicus | EC50 | = | 158.49 | nM | 6.8 | Dilator activity expressed as potency for relaxation of Tracheal strips percontr... | 11855989 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11855989 | 10.1021/jm010999g | Rattus norvegicus | 5 |
| 2299619 | 10.1021/jm00164a005 | Rattus norvegicus | 4 |
| 1920358 | 10.1021/jm00114a017 | Oryctolagus cuniculus | 3 |
| 2231602 | 10.1021/jm00173a019 | Cavia porcellus | 2 |
| - | 10.1016/S0960-894X(01)80835-0 | Rattus norvegicus | 2 |
| 11855989 | 10.1021/jm010999g | ATP-binding cassette sub-family C member 9 | 2 |
| 10090781 | 10.1021/jm981047m | Rattus norvegicus | 2 |
| 1920358 | 10.1021/jm00114a017 | Sus scrofa | 1 |
| 1447742 | 10.1021/jm00101a020 | Rattus norvegicus | 1 |
| 2299619 | 10.1021/jm00164a005 | Unchecked | 1 |
| 8336339 | 10.1021/jm00066a009 | Unchecked | 1 |
| 8336339 | 10.1021/jm00066a009 | Rattus norvegicus | 1 |
| - | 10.6019/CHEMBL5441142 | Schistosoma mansoni | 1 |
Data from ChEMBL 36 via Core Engine