Assay Detail
Functional
CHEMBL765023
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Drug concentration required to induce half maximal hyperpolarization in rabbit main pulmonary arteries
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
3-Methyl-2H-1-benzopyran potassium channel activators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 7.52 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL104552 | — | — | 1 | 8.52 |
| CHEMBL327249 | — | — | 1 | 7.96 |
| CHEMBL12552 | BIMAKALIM | 2.0 | 1 | 7.57 |
| CHEMBL318520 | EMAKALIM | 2.0 | 1 | 6.98 |
| CHEMBL49035 | CROMAKALIM | 2.0 | 1 | 6.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL104552 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL327249 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL12552 | BIMAKALIM | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL318520 | EMAKALIM | EC50 | = | 105.0 | nM | 6.98 |
| CHEMBL49035 | CROMAKALIM | EC50 | = | 263.0 | nM | 6.58 |