Assay Detail
Functional
CHEMBL857026
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Negative logarithm of the molar concentration required to relax rat aorta precontracted with 30 mM KCL by 50% of intrinsic activity
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Vasorelaxant activity of 2-fluoromethylbenzopyran K+ channel openers
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 26 | 7.74 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL419145 | — | — | 1 | 8.82 |
| CHEMBL96013 | — | — | 1 | 8.77 |
| CHEMBL318185 | — | — | 1 | 8.76 |
| CHEMBL328822 | — | — | 1 | 8.61 |
| CHEMBL98616 | — | — | 1 | 8.56 |
| CHEMBL100472 | — | — | 1 | 8.53 |
| CHEMBL99434 | — | — | 1 | 8.41 |
| CHEMBL330633 | — | — | 1 | 8.25 |
| CHEMBL95831 | — | — | 1 | 8.20 |
| CHEMBL321996 | — | — | 1 | 8.11 |
| CHEMBL439776 | — | — | 1 | 8.05 |
| CHEMBL95280 | — | — | 1 | 7.92 |
| CHEMBL316682 | — | — | 1 | 7.78 |
| CHEMBL430649 | — | — | 1 | 7.76 |
| CHEMBL99243 | — | — | 1 | 7.62 |
| CHEMBL323582 | — | — | 1 | 7.61 |
| CHEMBL97196 | — | — | 1 | 7.61 |
| CHEMBL99428 | — | — | 1 | 7.54 |
| CHEMBL12552 | BIMAKALIM | 2.0 | 1 | 7.52 |
| CHEMBL420443 | — | — | 1 | 7.07 |
| CHEMBL97816 | — | — | 1 | 6.99 |
| CHEMBL316708 | — | — | 1 | 6.83 |
| CHEMBL96000 | — | — | 1 | 6.79 |
| CHEMBL49035 | CROMAKALIM | 2.0 | 1 | 6.77 |
| CHEMBL1563246 | — | — | 1 | 6.28 |
| CHEMBL1159 | PINACIDIL ANHYDROUS | 4.0 | 1 | 6.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL419145 | — | EC50 | = | 1.514 | nM | 8.82 |
| CHEMBL96013 | — | EC50 | = | 1.698 | nM | 8.77 |
| CHEMBL318185 | — | EC50 | = | 1.738 | nM | 8.76 |
| CHEMBL328822 | — | EC50 | = | 2.455 | nM | 8.61 |
| CHEMBL98616 | — | EC50 | = | 2.754 | nM | 8.56 |
| CHEMBL100472 | — | EC50 | = | 2.951 | nM | 8.53 |
| CHEMBL99434 | — | EC50 | = | 3.89 | nM | 8.41 |
| CHEMBL330633 | — | EC50 | = | 5.623 | nM | 8.25 |
| CHEMBL95831 | — | EC50 | = | 6.31 | nM | 8.20 |
| CHEMBL321996 | — | EC50 | = | 7.762 | nM | 8.11 |
| CHEMBL439776 | — | EC50 | = | 8.913 | nM | 8.05 |
| CHEMBL95280 | — | EC50 | = | 12.02 | nM | 7.92 |
| CHEMBL316682 | — | EC50 | = | 16.6 | nM | 7.78 |
| CHEMBL430649 | — | EC50 | = | 17.38 | nM | 7.76 |
| CHEMBL99243 | — | EC50 | = | 23.99 | nM | 7.62 |
| CHEMBL323582 | — | EC50 | = | 24.55 | nM | 7.61 |
| CHEMBL97196 | — | EC50 | = | 24.55 | nM | 7.61 |
| CHEMBL99428 | — | EC50 | = | 28.84 | nM | 7.54 |
| CHEMBL12552 | BIMAKALIM | EC50 | = | 30.2 | nM | 7.52 |
| CHEMBL420443 | — | EC50 | = | 85.11 | nM | 7.07 |
| CHEMBL97816 | — | EC50 | = | 102.33 | nM | 6.99 |
| CHEMBL316708 | — | EC50 | = | 147.91 | nM | 6.83 |
| CHEMBL96000 | — | EC50 | = | 162.18 | nM | 6.79 |
| CHEMBL49035 | CROMAKALIM | EC50 | = | 169.82 | nM | 6.77 |
| CHEMBL1563246 | — | EC50 | = | 524.81 | nM | 6.28 |
| CHEMBL1159 | PINACIDIL ANHYDROUS | EC50 | = | 724.44 | nM | 6.14 |