Assay Detail
Functional
CHEMBL798101
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Dilator activity expressed as potency for relaxation of Tracheal strips percontracted with 0.6 uM carbachol
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
6-Sulfonylchromenes as highly potent K(ATP)-channel openers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 20 | 6.58 | 8.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL12305 | — | — | 1 | 8.01 |
| CHEMBL11983 | — | — | 1 | 7.88 |
| CHEMBL275679 | — | — | 1 | 7.88 |
| CHEMBL275758 | RILMAKALIM | 2.0 | 1 | 7.57 |
| CHEMBL269681 | — | — | 1 | 7.03 |
| CHEMBL269676 | — | — | 1 | 7.02 |
| CHEMBL273664 | — | — | 1 | 6.86 |
| CHEMBL12552 | BIMAKALIM | 2.0 | 1 | 6.80 |
| CHEMBL12138 | — | — | 1 | 6.74 |
| CHEMBL276151 | — | — | 1 | 6.69 |
| CHEMBL429004 | — | — | 1 | 6.65 |
| CHEMBL12359 | — | — | 1 | 6.31 |
| CHEMBL275277 | — | — | 1 | 6.22 |
| CHEMBL12614 | — | — | 1 | 6.00 |
| CHEMBL276693 | — | — | 1 | 5.88 |
| CHEMBL12380 | — | — | 1 | 5.86 |
| CHEMBL12778 | — | — | 1 | 5.71 |
| CHEMBL12139 | — | — | 1 | 5.00 |
| CHEMBL12698 | — | — | 1 | 4.99 |
| CHEMBL12339 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL12305 | — | EC50 | = | 9.772 | nM | 8.01 |
| CHEMBL11983 | — | EC50 | = | 13.18 | nM | 7.88 |
| CHEMBL275679 | — | EC50 | = | 13.18 | nM | 7.88 |
| CHEMBL275758 | RILMAKALIM | EC50 | = | 26.92 | nM | 7.57 |
| CHEMBL269681 | — | EC50 | = | 93.33 | nM | 7.03 |
| CHEMBL269676 | — | EC50 | = | 95.5 | nM | 7.02 |
| CHEMBL273664 | — | EC50 | = | 138.04 | nM | 6.86 |
| CHEMBL12552 | BIMAKALIM | EC50 | = | 158.49 | nM | 6.80 |
| CHEMBL12138 | — | EC50 | = | 181.97 | nM | 6.74 |
| CHEMBL276151 | — | EC50 | = | 204.17 | nM | 6.69 |
| CHEMBL429004 | — | EC50 | = | 223.87 | nM | 6.65 |
| CHEMBL12359 | — | EC50 | = | 489.78 | nM | 6.31 |
| CHEMBL275277 | — | EC50 | = | 602.56 | nM | 6.22 |
| CHEMBL12614 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL276693 | — | EC50 | = | 1318.26 | nM | 5.88 |
| CHEMBL12380 | — | EC50 | = | 1380.38 | nM | 5.86 |
| CHEMBL12778 | — | EC50 | = | 1949.84 | nM | 5.71 |
| CHEMBL12139 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL12698 | — | EC50 | = | 10232.93 | nM | 4.99 |
| CHEMBL12339 | — | EC50 | = | 84.5 | nM | - |