Assay Detail
Functional
CHEMBL683771
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of spontaneous tone in Guinea pig tracheal spiral strips.
38
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Trachea |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Relaxant activity of 4-amido-3,4-dihydro-2H-1-benzopyran-3-ols and 4-amido-2H-1-benzopyrans on guinea pig isolated trachealis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 5.90 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL714 | ALBUTEROL | 4.0 | 1 | 7.75 |
| CHEMBL104986 | — | — | 1 | 7.25 |
| CHEMBL103135 | — | — | 1 | 7.24 |
| CHEMBL12552 | BIMAKALIM | 2.0 | 1 | 7.05 |
| CHEMBL103414 | — | — | 1 | 6.57 |
| CHEMBL420659 | — | — | 3 | 6.44 |
| CHEMBL262553 | — | — | 1 | 6.39 |
| CHEMBL323149 | — | — | 1 | 6.27 |
| CHEMBL103852 | — | — | 1 | 6.19 |
| CHEMBL317658 | — | — | 1 | 6.18 |
| CHEMBL321100 | — | — | 1 | 6.14 |
| CHEMBL318520 | EMAKALIM | 2.0 | 1 | 6.12 |
| CHEMBL49035 | CROMAKALIM | 2.0 | 1 | 5.96 |
| CHEMBL302784 | — | — | 1 | 5.96 |
| CHEMBL322161 | — | — | 1 | 5.92 |
| CHEMBL274916 | — | — | 1 | 5.80 |
| CHEMBL103106 | — | — | 1 | 5.68 |
| CHEMBL317893 | — | — | 1 | 5.66 |
| CHEMBL105324 | — | — | 1 | 5.65 |
| CHEMBL105207 | — | — | 1 | 5.57 |
| CHEMBL102658 | — | — | 1 | 5.53 |
| CHEMBL1159 | PINACIDIL ANHYDROUS | 4.0 | 1 | 5.44 |
| CHEMBL101531 | — | — | 1 | 5.40 |
| CHEMBL317831 | — | — | 1 | 5.29 |
| CHEMBL320187 | — | — | 1 | 5.29 |
| CHEMBL104275 | — | — | 1 | 5.17 |
| CHEMBL104382 | — | — | 1 | 5.12 |
| CHEMBL320385 | — | — | 1 | 5.07 |
| CHEMBL323121 | — | — | 1 | 4.87 |
| CHEMBL1370561 | AMINOPHYLLINE | 4.0 | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL714 | ALBUTEROL | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL104986 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL103135 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL12552 | BIMAKALIM | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL103414 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL420659 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL262553 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL323149 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL103852 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL420659 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL317658 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL321100 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL318520 | EMAKALIM | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL302784 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL49035 | CROMAKALIM | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL322161 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL274916 | — | IC50 | = | 1570.0 | nM | 5.80 |
| CHEMBL103106 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL317893 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL105324 | — | IC50 | = | 2250.0 | nM | 5.65 |
| CHEMBL105207 | — | IC50 | = | 2680.0 | nM | 5.57 |
| CHEMBL102658 | — | IC50 | = | 2970.0 | nM | 5.53 |
| CHEMBL1159 | PINACIDIL ANHYDROUS | IC50 | = | 3630.0 | nM | 5.44 |
| CHEMBL101531 | — | IC50 | = | 3960.0 | nM | 5.40 |
| CHEMBL317831 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL320187 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL104275 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL104382 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL320385 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL420659 | — | IC50 | = | 12560.0 | nM | 4.90 |
| CHEMBL323121 | — | IC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL1370561 | AMINOPHYLLINE | IC50 | = | 20100.0 | nM | 4.70 |
| CHEMBL101432 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL318972 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL102278 | — | IC50 | > | 17000.0 | nM | - |
| CHEMBL103948 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL193 | NIFEDIPINE | IC50 | > | 20000.0 | nM | - |
| CHEMBL105379 | — | IC50 | > | 20000.0 | nM | - |