Compound Detail
CHEMBL1370561
AMINOPHYLLINE 💊 Approved Drug
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💊 Approved Drug
3
Targets
20
Activities
3
Assay Types
1
PK Parameters
20
Publications
18
Known Names
9
Indications
3
Mechanisms
Molecular Properties
180.2
MW (Da)
-1.04
ALogP
5
HBA
1
HBD
72.7
PSA (Ų)
0.56
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Protein |
| First Approval | 1940 |
| Availability | Prescription |
| Chirality | Achiral |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Phosphodiesterase 4 inhibitor | INHIBITOR | Phosphodiesterase 4 | ✓ | ✓ |
| Phosphodiesterase 3 inhibitor | INHIBITOR | Phosphodiesterase 3 | ✓ | ✓ |
| Adenosine receptor antagonist | ANTAGONIST | Adenosine receptor | ✓ | ✓ |
Indications
Asthma Lung Diseases, Obstructive Acute Kidney Injury Headache Heart Arrest Altitude Sickness Hypertension, Pulmonary Premature Birth Urinary Bladder Neoplasms
ATC Classification
R03DA05
aminophylline
Level 1: RESPIRATORY SYSTEM
Level 2: DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
R03DA55
aminophylline, combinations
Level 1: RESPIRATORY SYSTEM
Level 2: DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
Activity Summary
IC50 16 meas. best 4.78
EC50 3 meas. best 7.3
Kd 1 meas. best 7.32
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Trachea CHEMBL4296542 | Kd | 7.32 | 7.32 | 47.9 | 1 |
| Trachea CHEMBL4296542 | EC50 | 7.3 | 7.3 | 50.0 | 1 |
| Cavia porcellus CHEMBL369 | IC50 | 4.78 | 4.5283 | 16700.0 | 12 |
| Unchecked CHEMBL612545 | IC50 | 4.52 | 4.52 | 30000.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| AUC | 246.0 | hr | Cavia porcellus |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine