Assay Detail

CHEMBL684576

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Functional

Inhibitory effect on spasmogen (histamine) induced contraction of guinea pig tracheal strips.

ChEMBL ↗

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Target

Cavia porcellus (CHEMBL369) ↗

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Primary target Cavia porcellus

CHEMBL369

Anchored from Assay target.

Protein identity Cavia porcellus

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Cavia porcellus
Tissue	Trachea
Confidence	1 — Organism
Curated By	Intermediate

Target

Cavia porcellus (CHEMBL369) ↗

Type	ORGANISM
Organism	Cavia porcellus

Publication

New bronchodilators. 1. 1,5-Substituted 1H-imidazo[4,5-c]quinolin-4(5H)-ones.

Suzuki F, Kuroda T, Nakasato Y, Manabe H, Ohmori K, Kitamura S, Ichikawa S, Ohno T.
J Med Chem (1992) 35 : 4045 -4053
PubMed 1331454 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	5.08	5.67

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL434802	—	—	1	5.67
CHEMBL1370561	AMINOPHYLLINE	4.0	1	4.48

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL434802	—	IC50	=	2120.0	nM	5.67
CHEMBL1370561	AMINOPHYLLINE	IC50	=	33200.0	nM	4.48