Assay Detail
Functional
CHEMBL689697
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory effect on the contraction of guinea pig tracheal strips was examined for spontaneous contraction
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Trachea |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel antiasthmatic agents with dual activities of thromboxane A2 synthetase inhibition and bronchodilation. 2. 4-(3-Pyridyl)-1(2H)-phthalazinones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.30 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL335687 | — | — | 1 | 5.80 |
| CHEMBL130453 | — | — | 1 | 5.75 |
| CHEMBL1370561 | AMINOPHYLLINE | 4.0 | 1 | 4.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL335687 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL130453 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL1370561 | AMINOPHYLLINE | IC50 | = | 44000.0 | nM | 4.36 |