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Assay Detail

CHEMBL680815

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Functional
Tested in vitro for bronchodilatory activity by spontaneous tone inhibition in guinea pig tracheal strips
ChEMBL ↗
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Cavia porcellus
Tissue Trachea
Confidence 1 — Organism
Curated By Expert

Target

Cavia porcellus (CHEMBL369) ↗
Type ORGANISM
Organism Cavia porcellus

Publication

Novel antiasthmatic agents with dual activities of thromboxane A2 synthetase inhibition and bronchodilation. 1. 2-[2-(1-Imidazolyl)alkyl]-1(2H)-phthalazinones.
Yamaguchi M, Kamei K, Koga T, Akima M, Kuroki T, Ohi N.
J Med Chem (1993) 36 : 4052 -4060
PubMed 8258827 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 45 5.05 6.17

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL132117 — — 1 6.17
CHEMBL336582 — — 1 6.00
CHEMBL339814 — — 1 5.88
CHEMBL130987 — — 1 5.84
CHEMBL130448 — — 1 5.75
CHEMBL130618 — — 1 5.69
CHEMBL336393 — — 1 5.63
CHEMBL131897 — — 1 5.45
CHEMBL129928 — — 1 5.41
CHEMBL335635 — — 1 5.37
CHEMBL131421 — — 1 5.35
CHEMBL132286 — — 1 5.29
CHEMBL131123 — — 1 5.27
CHEMBL422078 — — 1 5.25
CHEMBL131237 — — 1 5.25
CHEMBL335034 — — 1 5.23
CHEMBL335917 — — 1 5.19
CHEMBL131376 — — 1 5.18
CHEMBL130168 — — 1 5.12
CHEMBL131225 — — 1 5.11
CHEMBL336131 — — 1 5.01
CHEMBL130566 — — 1 5.00
CHEMBL130046 — — 1 4.97
CHEMBL132445 — — 1 4.96
CHEMBL130917 — — 1 4.95
CHEMBL336187 — — 1 4.92
CHEMBL131487 — — 1 4.88
CHEMBL131435 — — 1 4.82
CHEMBL130619 — — 1 4.80
CHEMBL419970 — — 1 4.76

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL132117 — IC50 = 676.08 nM 6.17
CHEMBL336582 — IC50 = 1000.0 nM 6.00
CHEMBL339814 — IC50 = 1318.26 nM 5.88
CHEMBL130987 — IC50 = 1445.44 nM 5.84
CHEMBL130448 — IC50 = 1778.28 nM 5.75
CHEMBL130618 — IC50 = 2041.74 nM 5.69
CHEMBL336393 — IC50 = 2344.23 nM 5.63
CHEMBL131897 — IC50 = 3548.13 nM 5.45
CHEMBL129928 — IC50 = 3890.45 nM 5.41
CHEMBL335635 — IC50 = 4265.8 nM 5.37
CHEMBL131421 — IC50 = 4466.84 nM 5.35
CHEMBL132286 — IC50 = 5128.61 nM 5.29
CHEMBL131123 — IC50 = 5370.32 nM 5.27
CHEMBL422078 — IC50 = 5623.41 nM 5.25
CHEMBL131237 — IC50 = 5623.41 nM 5.25
CHEMBL335034 — IC50 = 5888.44 nM 5.23
CHEMBL335917 — IC50 = 6456.54 nM 5.19
CHEMBL131376 — IC50 = 6606.93 nM 5.18
CHEMBL130168 — IC50 = 7585.78 nM 5.12
CHEMBL131225 — IC50 = 7762.47 nM 5.11
CHEMBL336131 — IC50 = 9772.37 nM 5.01
CHEMBL130566 — IC50 = 10000.0 nM 5.00
CHEMBL130046 — IC50 = 10715.19 nM 4.97
CHEMBL132445 — IC50 = 10964.78 nM 4.96
CHEMBL130917 — IC50 = 11220.18 nM 4.95
CHEMBL336187 — IC50 = 12022.64 nM 4.92
CHEMBL131487 — IC50 = 13182.57 nM 4.88
CHEMBL131435 — IC50 = 15135.61 nM 4.82
CHEMBL130619 — IC50 = 15848.93 nM 4.80
CHEMBL419970 — IC50 = 17378.01 nM 4.76
CHEMBL130988 — IC50 = 18620.87 nM 4.73
CHEMBL335956 — IC50 = 23442.29 nM 4.63
CHEMBL132050 — IC50 = 23988.33 nM 4.62
CHEMBL335684 — IC50 = 25118.86 nM 4.60
CHEMBL131586 — IC50 = 26915.35 nM 4.57
CHEMBL130451 — IC50 = 34673.69 nM 4.46
CHEMBL340283 — IC50 = 42657.95 nM 4.37
CHEMBL337255 — IC50 = 42657.95 nM 4.37
CHEMBL1370561 AMINOPHYLLINE IC50 = 46773.51 nM 4.33
CHEMBL337484 — IC50 = 48977.88 nM 4.31
CHEMBL131316 — IC50 = 60255.96 nM 4.22
CHEMBL130709 — IC50 = 64565.42 nM 4.19
CHEMBL11662 OZAGREL IC50 > 1000000.0 nM -
CHEMBL130965 — IC50 > 100000.0 nM -
CHEMBL131075 — IC50 > 100000.0 nM -