Assay Detail
Functional
CHEMBL684572
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Inhibition of the Schulz-Dale (SD) reaction-induced contraction in trachea of guinea pig
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Trachea |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
New bronchodilators. 1. 1,5-Substituted 1H-imidazo[4,5-c]quinolin-4(5H)-ones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 5.29 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL544367 | — | — | 1 | 5.82 |
| CHEMBL130874 | — | — | 1 | 5.80 |
| CHEMBL340529 | — | — | 1 | 5.58 |
| CHEMBL131039 | — | — | 1 | 5.40 |
| CHEMBL131882 | — | — | 1 | 5.31 |
| CHEMBL128167 | — | — | 1 | 5.26 |
| CHEMBL130909 | — | — | 1 | 5.25 |
| CHEMBL1355736 | THEOPHYLLINE | 4.0 | 1 | 5.19 |
| CHEMBL337699 | — | — | 1 | 5.18 |
| CHEMBL130153 | — | — | 1 | 5.10 |
| CHEMBL132116 | — | — | 1 | 5.09 |
| CHEMBL128478 | — | — | 1 | 4.97 |
| CHEMBL1370561 | AMINOPHYLLINE | 4.0 | 1 | 4.78 |
| CHEMBL543658 | — | — | 1 | - |
| CHEMBL545067 | — | — | 1 | - |
| CHEMBL543423 | — | — | 1 | - |
| CHEMBL540328 | — | — | 1 | - |
| CHEMBL128139 | — | — | 1 | - |
| CHEMBL336508 | — | — | 1 | - |
| CHEMBL130152 | — | — | 1 | - |
| CHEMBL341177 | — | — | 1 | - |
| CHEMBL131663 | — | — | 1 | - |
| CHEMBL131522 | — | — | 1 | - |
| CHEMBL334380 | — | — | 1 | - |
| CHEMBL539290 | — | — | 1 | - |
| CHEMBL543656 | — | — | 1 | - |
| CHEMBL555755 | — | — | 1 | - |
| CHEMBL334582 | — | — | 1 | - |
| CHEMBL130730 | — | — | 1 | - |
| CHEMBL131067 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL544367 | — | IC50 | = | 1520.0 | nM | 5.82 |
| CHEMBL130874 | — | IC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL340529 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL131039 | — | IC50 | = | 3990.0 | nM | 5.40 |
| CHEMBL131882 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL128167 | — | IC50 | = | 5470.0 | nM | 5.26 |
| CHEMBL130909 | — | IC50 | = | 5620.0 | nM | 5.25 |
| CHEMBL1355736 | THEOPHYLLINE | IC50 | = | 6520.0 | nM | 5.19 |
| CHEMBL337699 | — | IC50 | = | 6580.0 | nM | 5.18 |
| CHEMBL130153 | — | IC50 | = | 7970.0 | nM | 5.10 |
| CHEMBL132116 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL128478 | — | IC50 | = | 10700.0 | nM | 4.97 |
| CHEMBL1370561 | AMINOPHYLLINE | IC50 | = | 16700.0 | nM | 4.78 |
| CHEMBL554240 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL130676 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL542476 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL543658 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL545067 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL543423 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL540328 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL128139 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL336508 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL130152 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL341177 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL131663 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL131522 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL334380 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL539290 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL543656 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL555755 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL334582 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL130730 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL131067 | — | IC50 | > | 30000.0 | nM | - |