Assay Detail
Functional
CHEMBL686347
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Schultz-Dale (SD) reaction in tracheal strip isolated from passively sensitized guinea pigs
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
New bronchodilators. 3. Imidazo[4,5-c][1,8]naphthyridin-4(5H)-ones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 5.54 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL323555 | — | — | 1 | 6.66 |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | 6.47 |
| CHEMBL321948 | — | — | 1 | 6.33 |
| CHEMBL95509 | — | — | 1 | 5.66 |
| CHEMBL143079 | — | — | 1 | 5.45 |
| CHEMBL329961 | — | — | 1 | 5.30 |
| CHEMBL1355736 | THEOPHYLLINE | 4.0 | 1 | 5.19 |
| CHEMBL330646 | — | — | 1 | 5.17 |
| CHEMBL95669 | — | — | 1 | 5.08 |
| CHEMBL342316 | — | — | 1 | 4.89 |
| CHEMBL1370561 | AMINOPHYLLINE | 4.0 | 1 | 4.78 |
| CHEMBL143980 | — | — | 1 | - |
| CHEMBL144070 | — | — | 1 | - |
| CHEMBL359396 | — | — | 1 | - |
| CHEMBL99568 | — | — | 1 | - |
| CHEMBL142602 | — | — | 1 | - |
| CHEMBL95361 | — | — | 1 | - |
| CHEMBL316563 | — | — | 1 | - |
| CHEMBL95394 | — | — | 1 | - |
| CHEMBL145286 | — | — | 1 | - |
| CHEMBL145659 | — | — | 1 | - |
| CHEMBL95276 | — | — | 1 | - |
| CHEMBL318674 | — | — | 1 | - |
| CHEMBL343207 | — | — | 1 | - |
| CHEMBL144569 | — | — | 1 | - |
| CHEMBL142601 | — | — | 1 | - |
| CHEMBL358745 | — | — | 1 | - |
| CHEMBL422483 | — | — | 1 | - |
| CHEMBL436015 | — | — | 1 | - |
| CHEMBL356988 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL323555 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL63 | ROLIPRAM | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL321948 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL95509 | — | IC50 | = | 2180.0 | nM | 5.66 |
| CHEMBL143079 | — | IC50 | = | 3570.0 | nM | 5.45 |
| CHEMBL329961 | — | IC50 | = | 4980.0 | nM | 5.30 |
| CHEMBL1355736 | THEOPHYLLINE | IC50 | = | 6520.0 | nM | 5.19 |
| CHEMBL330646 | — | IC50 | = | 6780.0 | nM | 5.17 |
| CHEMBL95669 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL342316 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL1370561 | AMINOPHYLLINE | IC50 | = | 16700.0 | nM | 4.78 |
| CHEMBL143980 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL144070 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL359396 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL99568 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL142602 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL95361 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL316563 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL95394 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL145286 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL145659 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL95276 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL318674 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL343207 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL144569 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL142601 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL358745 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL422483 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL436015 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL356988 | — | IC50 | > | 30000.0 | nM | - |