Assay Detail
Functional
CHEMBL798100
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Dilator activity expressed as potency for relaxation of Aortic rings precontracted with 25 mM K
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
6-Sulfonylchromenes as highly potent K(ATP)-channel openers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 21 | 7.44 | 8.76 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL12305 | — | — | 1 | 8.76 |
| CHEMBL275679 | — | — | 1 | 8.70 |
| CHEMBL275758 | RILMAKALIM | 2.0 | 1 | 8.62 |
| CHEMBL11983 | — | — | 1 | 8.60 |
| CHEMBL12339 | — | — | 1 | 8.51 |
| CHEMBL269681 | — | — | 1 | 8.32 |
| CHEMBL269676 | — | — | 1 | 7.79 |
| CHEMBL276151 | — | — | 1 | 7.79 |
| CHEMBL12552 | BIMAKALIM | 2.0 | 1 | 7.79 |
| CHEMBL12138 | — | — | 1 | 7.76 |
| CHEMBL273664 | — | — | 1 | 7.75 |
| CHEMBL12489 | — | — | 1 | 7.25 |
| CHEMBL429004 | — | — | 1 | 7.16 |
| CHEMBL275277 | — | — | 1 | 7.07 |
| CHEMBL12614 | — | — | 1 | 6.96 |
| CHEMBL12359 | — | — | 1 | 6.93 |
| CHEMBL12380 | — | — | 1 | 6.58 |
| CHEMBL276693 | — | — | 1 | 6.28 |
| CHEMBL12778 | — | — | 1 | 6.17 |
| CHEMBL12139 | — | — | 1 | 5.85 |
| CHEMBL12698 | — | — | 1 | 5.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL12305 | — | EC50 | = | 1.738 | nM | 8.76 |
| CHEMBL275679 | — | EC50 | = | 1.995 | nM | 8.70 |
| CHEMBL275758 | RILMAKALIM | EC50 | = | 2.399 | nM | 8.62 |
| CHEMBL11983 | — | EC50 | = | 2.512 | nM | 8.60 |
| CHEMBL12339 | — | EC50 | = | 3.09 | nM | 8.51 |
| CHEMBL269681 | — | EC50 | = | 4.786 | nM | 8.32 |
| CHEMBL269676 | — | EC50 | = | 16.22 | nM | 7.79 |
| CHEMBL276151 | — | EC50 | = | 16.22 | nM | 7.79 |
| CHEMBL12552 | BIMAKALIM | EC50 | = | 16.22 | nM | 7.79 |
| CHEMBL12138 | — | EC50 | = | 17.38 | nM | 7.76 |
| CHEMBL273664 | — | EC50 | = | 17.78 | nM | 7.75 |
| CHEMBL12489 | — | EC50 | = | 56.23 | nM | 7.25 |
| CHEMBL429004 | — | EC50 | = | 69.18 | nM | 7.16 |
| CHEMBL275277 | — | EC50 | = | 85.11 | nM | 7.07 |
| CHEMBL12614 | — | EC50 | = | 109.65 | nM | 6.96 |
| CHEMBL12359 | — | EC50 | = | 117.49 | nM | 6.93 |
| CHEMBL12380 | — | EC50 | = | 263.03 | nM | 6.58 |
| CHEMBL276693 | — | EC50 | = | 524.81 | nM | 6.28 |
| CHEMBL12778 | — | EC50 | = | 676.08 | nM | 6.17 |
| CHEMBL12139 | — | EC50 | = | 1412.54 | nM | 5.85 |
| CHEMBL12698 | — | EC50 | = | 2089.3 | nM | 5.68 |