Assay Detail
Functional
CHEMBL765024
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Relaxing effect by measuring inhibition of noradrenaline-induced contractions in rabbit main pulmonary arteries
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
3-Methyl-2H-1-benzopyran potassium channel activators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.33 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL104552 | — | — | 1 | 8.70 |
| CHEMBL327249 | — | — | 1 | 7.58 |
| CHEMBL12552 | BIMAKALIM | 2.0 | 1 | 7.24 |
| CHEMBL318520 | EMAKALIM | 2.0 | 1 | 6.76 |
| CHEMBL49035 | CROMAKALIM | 2.0 | 1 | 6.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL104552 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL327249 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL12552 | BIMAKALIM | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL318520 | EMAKALIM | IC50 | = | 174.0 | nM | 6.76 |
| CHEMBL49035 | CROMAKALIM | IC50 | = | 420.0 | nM | 6.38 |