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Assay Detail

CHEMBL763207

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Functional
Agonistic activity against progesterone receptor in alkaline phosphatase assay using human T47D breast carcinoma cell line
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Cell Type T47D
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Progesterone receptor (CHEMBL208)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Potent nonsteroidal progesterone receptor agonists: synthesis and SAR study of 6-aryl benzoxazines.
Zhang P, Terefenko EA, Fensome A, Zhang Z, Zhu Y, Cohen J, Winneker R, Wrobel J, Yardley J.
Bioorg Med Chem Lett (2002) 12 : 787 -790
PubMed 11859003 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 28 8.60 9.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL717 MEDROXYPROGESTERONE ACETATE 4.0 1 9.92
CHEMBL167405 1 9.70
CHEMBL164139 1 9.46
CHEMBL167844 1 9.10
CHEMBL351751 1 9.05
CHEMBL103 PROGESTERONE 4.0 1 9.04
CHEMBL164188 1 8.98
CHEMBL167570 1 8.77
CHEMBL167928 1 8.62
CHEMBL164187 1 8.62
CHEMBL165148 1 8.59
CHEMBL164082 1 8.54
CHEMBL164080 1 8.46
CHEMBL167492 1 8.34
CHEMBL165215 1 8.09
CHEMBL354327 1 8.04
CHEMBL350745 1 7.96
CHEMBL165612 1 7.64
CHEMBL165141 1 7.50
CHEMBL164908 1 7.50
CHEMBL165055 1 -
CHEMBL163833 1 -
CHEMBL350283 1 -
CHEMBL167620 1 -
CHEMBL349398 1 -
CHEMBL164331 1 -
CHEMBL164140 1 -
CHEMBL423084 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL717 MEDROXYPROGESTERONE ACETATE EC50 = 0.12 nM 9.92
CHEMBL167405 EC50 = 0.2 nM 9.70
CHEMBL164139 EC50 = 0.35 nM 9.46
CHEMBL167844 EC50 = 0.8 nM 9.10
CHEMBL351751 EC50 = 0.9 nM 9.05
CHEMBL103 PROGESTERONE EC50 = 0.92 nM 9.04
CHEMBL164188 EC50 = 1.05 nM 8.98
CHEMBL167570 EC50 = 1.7 nM 8.77
CHEMBL167928 EC50 = 2.4 nM 8.62
CHEMBL164187 EC50 = 2.4 nM 8.62
CHEMBL165148 EC50 = 2.6 nM 8.59
CHEMBL164082 EC50 = 2.9 nM 8.54
CHEMBL164080 EC50 = 3.5 nM 8.46
CHEMBL167492 EC50 = 4.55 nM 8.34
CHEMBL165215 EC50 = 8.2 nM 8.09
CHEMBL354327 EC50 = 9.2 nM 8.04
CHEMBL350745 EC50 = 10.9 nM 7.96
CHEMBL165612 EC50 = 23.0 nM 7.64
CHEMBL165141 EC50 = 32.0 nM 7.50
CHEMBL164908 EC50 = 32.0 nM 7.50
CHEMBL165055 EC50 > 10000.0 nM -
CHEMBL163833 EC50 > 10000.0 nM -
CHEMBL350283 EC50 > 10000.0 nM -
CHEMBL167620 EC50 > 10000.0 nM -
CHEMBL349398 EC50 > 10000.0 nM -
CHEMBL164331 EC50 > 10000.0 nM -
CHEMBL164140 EC50 > 10000.0 nM -
CHEMBL423084 EC50 > 10000.0 nM -