Assay Detail
Functional
CHEMBL763445
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonistic activity against Progesterone receptor (PR) in transcriptional activation assay in human T47D breast carcinoma cell line
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | T47D |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Potent nonsteroidal progesterone receptor agonists: synthesis and SAR study of 6-aryl benzoxazines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.43 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1276308 | MIFEPRISTONE | 4.0 | 1 | 9.70 |
| CHEMBL117465 | — | — | 1 | 7.43 |
| CHEMBL163833 | — | — | 1 | 7.33 |
| CHEMBL164140 | — | — | 1 | 7.29 |
| CHEMBL167620 | — | — | 1 | 7.03 |
| CHEMBL350283 | — | — | 1 | 6.99 |
| CHEMBL349398 | — | — | 1 | 6.90 |
| CHEMBL165055 | — | — | 1 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1276308 | MIFEPRISTONE | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL117465 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL163833 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL164140 | — | IC50 | = | 51.2 | nM | 7.29 |
| CHEMBL167620 | — | IC50 | = | 92.6 | nM | 7.03 |
| CHEMBL350283 | — | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL349398 | — | IC50 | = | 126.6 | nM | 6.90 |
| CHEMBL165055 | — | IC50 | = | 158.8 | nM | 6.80 |