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Assay Detail

CHEMBL763447

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity against progesterone receptor using human T47D breast carcinoma cell line
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Cell Type T47D
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Progesterone receptor (CHEMBL208)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Potent nonsteroidal progesterone receptor agonists: synthesis and SAR study of 6-aryl benzoxazines.
Zhang P, Terefenko EA, Fensome A, Zhang Z, Zhu Y, Cohen J, Winneker R, Wrobel J, Yardley J.
Bioorg Med Chem Lett (2002) 12 : 787 -790
PubMed 11859003 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 24 7.26 8.54

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL164187 1 8.54
CHEMBL167844 1 8.31
CHEMBL167570 1 8.15
CHEMBL164695 1 8.14
CHEMBL351751 1 8.10
CHEMBL167405 1 8.09
CHEMBL167928 1 8.05
CHEMBL165141 1 8.00
CHEMBL164139 1 7.94
CHEMBL164080 1 7.92
CHEMBL165148 1 7.64
CHEMBL165215 1 7.61
CHEMBL164188 1 7.57
CHEMBL350745 1 7.38
CHEMBL164082 1 7.38
CHEMBL167492 1 6.95
CHEMBL165612 1 6.78
CHEMBL164908 1 6.67
CHEMBL350283 1 6.52
CHEMBL164140 1 5.77
CHEMBL165055 1 5.75
CHEMBL167620 1 5.69
CHEMBL423084 1 5.68
CHEMBL349398 1 5.52

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL164187 IC50 = 2.9 nM 8.54
CHEMBL167844 IC50 = 4.9 nM 8.31
CHEMBL167570 IC50 = 7.1 nM 8.15
CHEMBL164695 IC50 = 7.3 nM 8.14
CHEMBL351751 IC50 = 7.9 nM 8.10
CHEMBL167405 IC50 = 8.1 nM 8.09
CHEMBL167928 IC50 = 9.0 nM 8.05
CHEMBL165141 IC50 = 10.0 nM 8.00
CHEMBL164139 IC50 = 11.5 nM 7.94
CHEMBL164080 IC50 = 12.0 nM 7.92
CHEMBL165148 IC50 = 23.0 nM 7.64
CHEMBL165215 IC50 = 24.7 nM 7.61
CHEMBL164188 IC50 = 27.0 nM 7.57
CHEMBL350745 IC50 = 42.0 nM 7.38
CHEMBL164082 IC50 = 41.3 nM 7.38
CHEMBL167492 IC50 = 113.4 nM 6.95
CHEMBL165612 IC50 = 166.0 nM 6.78
CHEMBL164908 IC50 = 212.5 nM 6.67
CHEMBL350283 IC50 = 301.0 nM 6.52
CHEMBL164140 IC50 = 1682.0 nM 5.77
CHEMBL165055 IC50 = 1793.0 nM 5.75
CHEMBL167620 IC50 = 2060.0 nM 5.69
CHEMBL423084 IC50 = 2087.0 nM 5.68
CHEMBL349398 IC50 = 3042.0 nM 5.52