Assay Detail
Functional
CHEMBL763450
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity against human progesterone receptor (hPR) in T47D human breast cancer cell line
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | T47D |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Nonsteroidal progesterone receptor antagonists based on 6-thiophenehydroquinolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.96 | 8.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1908373 | ONAPRISTONE | 2.0 | 1 | 8.48 |
| CHEMBL133656 | — | — | 1 | 7.16 |
| CHEMBL339399 | — | — | 1 | 7.15 |
| CHEMBL134786 | — | — | 1 | 7.11 |
| CHEMBL132193 | — | — | 1 | 7.10 |
| CHEMBL337885 | — | — | 1 | 6.99 |
| CHEMBL133794 | — | — | 1 | 6.98 |
| CHEMBL335992 | — | — | 1 | 6.97 |
| CHEMBL132195 | — | — | 1 | 6.92 |
| CHEMBL132192 | — | — | 1 | 6.92 |
| CHEMBL131855 | — | — | 1 | 6.91 |
| CHEMBL133661 | — | — | 1 | 6.82 |
| CHEMBL334890 | — | — | 1 | 6.82 |
| CHEMBL538158 | — | — | 1 | 6.72 |
| CHEMBL132950 | — | — | 1 | 6.60 |
| CHEMBL134258 | — | — | 1 | 6.56 |
| CHEMBL337199 | — | — | 1 | 6.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1908373 | ONAPRISTONE | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL133656 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL339399 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL134786 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL132193 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL337885 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL133794 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL335992 | — | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL132195 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL132192 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL131855 | — | IC50 | = | 123.0 | nM | 6.91 |
| CHEMBL133661 | — | IC50 | = | 151.0 | nM | 6.82 |
| CHEMBL334890 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL538158 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL132950 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL134258 | — | IC50 | = | 278.0 | nM | 6.56 |
| CHEMBL337199 | — | IC50 | = | 700.0 | nM | 6.16 |