Compound Detail
CHEMBL337199
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL337199 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BHNUPBIVKPEBRD-UHFFFAOYSA-N |
1
Targets
4
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
255.4
MW (Da)
5.02
ALogP
2
HBA
1
HBD
12.0
PSA (Ų)
0.75
QED
1
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.38
Ki 2 meas. best 6.63
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Progesterone receptor CHEMBL208 | Ki | 6.63 | 6.625 | 234.4 | 2 |
| Progesterone receptor CHEMBL208 | IC50 | 6.38 | 6.27 | 416.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Progesterone receptor | Ki | = | 234.42 | nM | 6.63 | Displacement of [3H]progesterone from Progesterone receptor | 16821785 |
| Progesterone receptor | Ki | = | 237.0 | nM | 6.62 | Binding affinity against human progesterone receptor (hPR) in a competitive bind... | 10743938 |
| Progesterone receptor | IC50 | = | 416.0 | nM | 6.38 | Antagonist activity against human progesterone receptor (hPR) using cotransfecti... | 10743938 |
| Progesterone receptor | IC50 | = | 700.0 | nM | 6.16 | Antagonist activity against human progesterone receptor (hPR) in T47D human brea... | 10743938 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10743938 | 10.1016/s0960-894x(00)00011-1 | Progesterone receptor | 9 |
| 16821785 | 10.1021/jm060234e | Progesterone receptor | 1 |
Data from ChEMBL 36 via Core Engine