Assay Detail
Binding
CHEMBL765847
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Binding affinity against human progesterone receptor (hPR) in a competitive binding assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Nonsteroidal progesterone receptor antagonists based on 6-thiophenehydroquinolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 7.63 | 8.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL133656 | — | — | 1 | 8.59 |
| CHEMBL335992 | — | — | 1 | 8.46 |
| CHEMBL103 | PROGESTERONE | 4.0 | 1 | 8.46 |
| CHEMBL132889 | — | — | 1 | 8.41 |
| CHEMBL134260 | — | — | 1 | 8.21 |
| CHEMBL117465 | — | — | 1 | 8.00 |
| CHEMBL133661 | — | — | 1 | 7.92 |
| CHEMBL131681 | — | — | 1 | 7.91 |
| CHEMBL1908373 | ONAPRISTONE | 2.0 | 1 | 7.75 |
| CHEMBL133794 | — | — | 1 | 7.60 |
| CHEMBL131855 | — | — | 1 | 7.58 |
| CHEMBL339399 | — | — | 1 | 7.51 |
| CHEMBL132195 | — | — | 1 | 7.51 |
| CHEMBL538158 | — | — | 1 | 7.50 |
| CHEMBL334890 | — | — | 1 | 7.44 |
| CHEMBL337885 | — | — | 1 | 7.43 |
| CHEMBL132193 | — | — | 1 | 7.26 |
| CHEMBL134786 | — | — | 1 | 7.10 |
| CHEMBL337199 | — | — | 1 | 6.62 |
| CHEMBL132950 | — | — | 1 | 6.60 |
| CHEMBL132192 | — | — | 1 | 6.36 |
| CHEMBL134258 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL133656 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL335992 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL103 | PROGESTERONE | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL132889 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL134260 | — | Ki | = | 6.2 | nM | 8.21 |
| CHEMBL117465 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL133661 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL131681 | — | Ki | = | 12.4 | nM | 7.91 |
| CHEMBL1908373 | ONAPRISTONE | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL133794 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL131855 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL339399 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL132195 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL538158 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL334890 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL337885 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL132193 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL134786 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL337199 | — | Ki | = | 237.0 | nM | 6.62 |
| CHEMBL132950 | — | Ki | = | 249.0 | nM | 6.60 |
| CHEMBL132192 | — | Ki | = | 433.0 | nM | 6.36 |
| CHEMBL134258 | — | Ki | > | 100.0 | nM | - |