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Assay Detail

CHEMBL864183

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Binding
Displacement of [3H]progesterone from Progesterone receptor
ChEMBL ↗
74
Total Activities
74
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Progesterone receptor (CHEMBL208) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Docking and three-dimensional quantitative structure-activity relationship (3D QSAR) analyses of nonsteroidal progesterone receptor ligands.
Söderholm AA, Lehtovuori PT, Nyrönen TH.
J Med Chem (2006) 49 : 4261 -4268
PubMed 16821785 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 74 7.59 9.47

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL717 MEDROXYPROGESTERONE ACETATE 4.0 1 9.47
CHEMBL433403 — — 1 8.82
CHEMBL330527 — — 1 8.72
CHEMBL62700 — — 1 8.68
CHEMBL93690 — — 1 8.64
CHEMBL133656 — — 1 8.59
CHEMBL65014 — — 1 8.51
CHEMBL327847 — — 1 8.51
CHEMBL335992 — — 1 8.46
CHEMBL92750 — — 1 8.46
CHEMBL103 PROGESTERONE 4.0 1 8.46
CHEMBL328506 — — 1 8.44
CHEMBL132889 — — 1 8.41
CHEMBL62227 — — 1 8.35
CHEMBL117308 — — 1 8.30
CHEMBL65743 — — 1 8.25
CHEMBL64913 — — 1 8.21
CHEMBL64294 — — 1 8.17
CHEMBL62981 — — 1 8.10
CHEMBL117586 — — 1 8.00
CHEMBL117465 — — 1 8.00
CHEMBL313418 — — 1 7.95
CHEMBL133661 — — 1 7.92
CHEMBL62761 — — 1 7.91
CHEMBL131681 — — 1 7.91
CHEMBL92089 — — 1 7.91
CHEMBL92730 — — 1 7.89
CHEMBL64123 — — 1 7.89
CHEMBL418684 — — 1 7.87
CHEMBL329198 — — 1 7.85

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL717 MEDROXYPROGESTERONE ACETATE Ki = 0.3388 nM 9.47
CHEMBL433403 — Ki = 1.514 nM 8.82
CHEMBL330527 — Ki = 1.905 nM 8.72
CHEMBL62700 — Ki = 2.089 nM 8.68
CHEMBL93690 — Ki = 2.291 nM 8.64
CHEMBL133656 — Ki = 2.57 nM 8.59
CHEMBL65014 — Ki = 3.09 nM 8.51
CHEMBL327847 — Ki = 3.09 nM 8.51
CHEMBL335992 — Ki = 3.467 nM 8.46
CHEMBL92750 — Ki = 3.467 nM 8.46
CHEMBL103 PROGESTERONE Ki = 3.467 nM 8.46
CHEMBL328506 — Ki = 3.631 nM 8.44
CHEMBL132889 — Ki = 3.89 nM 8.41
CHEMBL62227 — Ki = 4.467 nM 8.35
CHEMBL117308 — Ki = 5.012 nM 8.30
CHEMBL65743 — Ki = 5.623 nM 8.25
CHEMBL64913 — Ki = 6.166 nM 8.21
CHEMBL64294 — Ki = 6.761 nM 8.17
CHEMBL62981 — Ki = 7.943 nM 8.10
CHEMBL117586 — Ki = 10.0 nM 8.00
CHEMBL117465 — Ki = 10.0 nM 8.00
CHEMBL313418 — Ki = 11.22 nM 7.95
CHEMBL133661 — Ki = 12.02 nM 7.92
CHEMBL92089 — Ki = 12.3 nM 7.91
CHEMBL62761 — Ki = 12.3 nM 7.91
CHEMBL131681 — Ki = 12.3 nM 7.91
CHEMBL92730 — Ki = 12.88 nM 7.89
CHEMBL64123 — Ki = 12.88 nM 7.89
CHEMBL418684 — Ki = 13.49 nM 7.87
CHEMBL329198 — Ki = 14.13 nM 7.85
CHEMBL63870 — Ki = 15.14 nM 7.82
CHEMBL91927 — Ki = 15.49 nM 7.81
CHEMBL63015 — Ki = 16.6 nM 7.78
CHEMBL115904 — Ki = 19.05 nM 7.72
CHEMBL65079 — Ki = 19.5 nM 7.71
CHEMBL93027 — Ki = 19.95 nM 7.70
CHEMBL431280 — Ki = 20.89 nM 7.68
CHEMBL446418 — Ki = 23.99 nM 7.62
CHEMBL133794 — Ki = 25.12 nM 7.60
CHEMBL131855 — Ki = 25.7 nM 7.59
CHEMBL328523 — Ki = 28.84 nM 7.54
CHEMBL90766 — Ki = 28.84 nM 7.54
CHEMBL132195 — Ki = 30.9 nM 7.51
CHEMBL339399 — Ki = 30.9 nM 7.51
CHEMBL538158 — Ki = 32.36 nM 7.49
CHEMBL334890 — Ki = 36.31 nM 7.44
CHEMBL337885 — Ki = 37.15 nM 7.43
CHEMBL294116 — Ki = 44.67 nM 7.35
CHEMBL62731 — Ki = 44.67 nM 7.35
CHEMBL132193 — Ki = 54.95 nM 7.26