Compound Detail
CHEMBL62731
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Basic Information
| ChEMBL ID | CHEMBL62731 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WZHDIERNMYGFAD-LSCVHKIXSA-N |
1
Targets
4
Activities
3
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
332.4
MW (Da)
5.36
ALogP
3
HBA
1
HBD
45.0
PSA (Ų)
0.66
QED
1
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 7.35
EC50 1 meas. best 5.57
IC50 1 meas. best 7.19
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Progesterone receptor CHEMBL208 | Ki | 7.35 | 7.35 | 44.7 | 2 |
| Progesterone receptor CHEMBL208 | IC50 | 7.19 | 7.19 | 65.0 | 1 |
| Progesterone receptor CHEMBL208 | EC50 | 5.57 | 5.57 | 2700.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Progesterone receptor | Ki | = | 45.0 | nM | 7.35 | Binding affinity to human progesterone receptor | 12781197 |
| Progesterone receptor | Ki | = | 44.67 | nM | 7.35 | Displacement of [3H]progesterone from Progesterone receptor | 16821785 |
| Progesterone receptor | IC50 | = | 65.0 | nM | 7.19 | Inhibitory concentration for antagonistic activity towards human progesterone re... | 12781197 |
| Progesterone receptor | EC50 | = | 2700.0 | nM | 5.57 | Effective concentration for agonist activity towards human progesterone receptor... | 12781197 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 12781197 | 10.1016/s0960-894x(03)00255-5 | Progesterone receptor | 5 |
| 16821785 | 10.1021/jm060234e | Progesterone receptor | 1 |
Data from ChEMBL 36 via Core Engine