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Assay Detail

CHEMBL765838

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Binding
Binding affinity to human progesterone receptor
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Progesterone receptor (CHEMBL208)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and biological activity of 5-methylidene 1,2-dihydrochromeno[3,4-f]quinoline derivatives as progesterone receptor modulators.
Zhi L, Tegley CM, Pio B, Edwards JP, Jones TK, Marschke KB, Mais DE, Risek B, Schrader WT.
Bioorg Med Chem Lett (2003) 13 : 2071 -2074
PubMed 12781197 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 16 8.37 9.47

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL292284 1 9.47
CHEMBL302362 1 9.18
CHEMBL1276308 MIFEPRISTONE 4.0 1 8.96
CHEMBL62700 1 8.68
CHEMBL65014 1 8.51
CHEMBL103 PROGESTERONE 4.0 1 8.46
CHEMBL64913 1 8.21
CHEMBL65929 1 8.20
CHEMBL62981 1 8.10
CHEMBL63015 1 7.78
CHEMBL65410 1 7.58
CHEMBL62731 1 7.35
CHEMBL65689 1 -
CHEMBL65227 1 -
CHEMBL303768 1 -
CHEMBL418670 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL292284 Ki = 0.34 nM 9.47
CHEMBL302362 Ki = 0.66 nM 9.18
CHEMBL1276308 MIFEPRISTONE Ki = 1.1 nM 8.96
CHEMBL62700 Ki = 2.1 nM 8.68
CHEMBL65014 Ki = 3.1 nM 8.51
CHEMBL103 PROGESTERONE Ki = 3.5 nM 8.46
CHEMBL64913 Ki = 6.1 nM 8.21
CHEMBL65929 Ki = 6.3 nM 8.20
CHEMBL62981 Ki = 8.0 nM 8.10
CHEMBL63015 Ki = 16.7 nM 7.78
CHEMBL65410 Ki = 26.0 nM 7.58
CHEMBL62731 Ki = 45.0 nM 7.35
CHEMBL65689 Ki > 100.0 nM -
CHEMBL65227 Ki > 100.0 nM -
CHEMBL303768 Ki > 100.0 nM -
CHEMBL418670 Ki > 100.0 nM -