Assay Detail
Functional
CHEMBL768817
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration for antagonistic activity towards human progesterone receptor (hPR) using the cotransfection assay in CV-1 cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CV-1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and biological activity of 5-methylidene 1,2-dihydrochromeno[3,4-f]quinoline derivatives as progesterone receptor modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.86 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1276308 | MIFEPRISTONE | 4.0 | 1 | 9.52 |
| CHEMBL62731 | — | — | 1 | 7.19 |
| CHEMBL65227 | — | — | 1 | 6.91 |
| CHEMBL65689 | — | — | 1 | 6.61 |
| CHEMBL418670 | — | — | 1 | 6.10 |
| CHEMBL63015 | — | — | 1 | 6.01 |
| CHEMBL303768 | — | — | 1 | 5.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1276308 | MIFEPRISTONE | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL62731 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL65227 | — | IC50 | = | 124.0 | nM | 6.91 |
| CHEMBL65689 | — | IC50 | = | 243.0 | nM | 6.61 |
| CHEMBL418670 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL63015 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL303768 | — | IC50 | = | 1930.0 | nM | 5.71 |