Assay Detail
Binding
CHEMBL763452
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vivo inhibition of ram seminal vesicle Prostaglandin G/H synthase 1 activity by determining PGE-2 by RIA
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Ovis aries |
| Tissue | Seminal vesicle |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
SAR of 2,6-diamino-3,5-difluoropyridinyl substituted heterocycles as novel p38MAP kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.17 | 5.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL304523 | — | — | 1 | 5.20 |
| CHEMBL291427 | — | — | 1 | 4.35 |
| CHEMBL66601 | — | — | 1 | 4.00 |
| CHEMBL65541 | — | — | 1 | 4.00 |
| CHEMBL307336 | — | — | 1 | 4.00 |
| CHEMBL66600 | — | — | 1 | 4.00 |
| CHEMBL306667 | — | — | 1 | 4.00 |
| CHEMBL291834 | — | — | 1 | 4.00 |
| CHEMBL304416 | — | — | 1 | 4.00 |
| CHEMBL63983 | — | — | 1 | - |
| CHEMBL63442 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL304523 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL291427 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL66601 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL65541 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL307336 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL66600 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL306667 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL291834 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL304416 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL63983 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL63442 | — | IC50 | > | 100000.0 | nM | - |