Assay Detail
Functional
CHEMBL763472
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]TCP from PCP receptor in tissue preparation of whole rat brain minus cerebellum.
45
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Analogues of the dioxolanes dexoxadrol and etoxadrol as potential phencyclidine-like agents. Synthesis and structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 45 | 5.89 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL287572 | — | — | 1 | 7.92 |
| CHEMBL26639 | — | — | 1 | 7.84 |
| CHEMBL26714 | — | — | 1 | 7.44 |
| CHEMBL281422 | — | — | 1 | 7.35 |
| CHEMBL280739 | — | — | 1 | 7.23 |
| CHEMBL284666 | — | — | 1 | 7.16 |
| CHEMBL275528 | PHENCYCLIDINE | 2.0 | 1 | 7.10 |
| CHEMBL305904 | ETOXADROL | 2.0 | 1 | 6.97 |
| CHEMBL1165411 | DEXOXADROL | 2.0 | 1 | 6.95 |
| CHEMBL282809 | — | — | 1 | 6.91 |
| CHEMBL26985 | — | — | 1 | 6.70 |
| CHEMBL287645 | — | — | 1 | 6.69 |
| CHEMBL284404 | — | — | 1 | 6.53 |
| CHEMBL281053 | — | — | 1 | 6.49 |
| CHEMBL26022 | — | — | 1 | 6.31 |
| CHEMBL282383 | — | — | 1 | 6.23 |
| CHEMBL28121 | — | — | 1 | 6.22 |
| CHEMBL416562 | — | — | 1 | 6.19 |
| CHEMBL282598 | — | — | 1 | 6.15 |
| CHEMBL417117 | — | — | 1 | 6.07 |
| CHEMBL284633 | — | — | 1 | 5.91 |
| CHEMBL26840 | — | — | 1 | 5.88 |
| CHEMBL26735 | — | — | 1 | 5.85 |
| CHEMBL284413 | — | — | 1 | 5.55 |
| CHEMBL412875 | — | — | 1 | 5.48 |
| CHEMBL424408 | — | — | 1 | 5.46 |
| CHEMBL26481 | — | — | 1 | 5.36 |
| CHEMBL430915 | — | — | 1 | 5.17 |
| CHEMBL27946 | — | — | 1 | 5.16 |
| CHEMBL287654 | — | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL287572 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL26639 | — | Ki | = | 14.3 | nM | 7.84 |
| CHEMBL26714 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL281422 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL280739 | — | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL284666 | — | Ki | = | 69.0 | nM | 7.16 |
| CHEMBL275528 | PHENCYCLIDINE | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL305904 | ETOXADROL | Ki | = | 107.0 | nM | 6.97 |
| CHEMBL1165411 | DEXOXADROL | Ki | = | 112.0 | nM | 6.95 |
| CHEMBL282809 | — | Ki | = | 124.0 | nM | 6.91 |
| CHEMBL26985 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL287645 | — | Ki | = | 205.0 | nM | 6.69 |
| CHEMBL284404 | — | Ki | = | 293.0 | nM | 6.53 |
| CHEMBL281053 | — | Ki | = | 325.0 | nM | 6.49 |
| CHEMBL26022 | — | Ki | = | 489.0 | nM | 6.31 |
| CHEMBL282383 | — | Ki | = | 590.0 | nM | 6.23 |
| CHEMBL28121 | — | Ki | = | 607.0 | nM | 6.22 |
| CHEMBL416562 | — | Ki | = | 649.0 | nM | 6.19 |
| CHEMBL282598 | — | Ki | = | 703.0 | nM | 6.15 |
| CHEMBL417117 | — | Ki | = | 847.0 | nM | 6.07 |
| CHEMBL284633 | — | Ki | = | 1230.0 | nM | 5.91 |
| CHEMBL26840 | — | Ki | = | 1320.0 | nM | 5.88 |
| CHEMBL26735 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL284413 | — | Ki | = | 2800.0 | nM | 5.55 |
| CHEMBL412875 | — | Ki | = | 3300.0 | nM | 5.48 |
| CHEMBL424408 | — | Ki | = | 3450.0 | nM | 5.46 |
| CHEMBL26481 | — | Ki | = | 4400.0 | nM | 5.36 |
| CHEMBL430915 | — | Ki | = | 6800.0 | nM | 5.17 |
| CHEMBL287654 | — | Ki | = | 6900.0 | nM | 5.16 |
| CHEMBL27946 | — | Ki | = | 7000.0 | nM | 5.16 |
| CHEMBL26724 | — | Ki | = | 7300.0 | nM | 5.14 |
| CHEMBL27050 | — | Ki | = | 8300.0 | nM | 5.08 |
| CHEMBL28119 | — | Ki | = | 8400.0 | nM | 5.08 |
| CHEMBL283893 | — | Ki | = | 9000.0 | nM | 5.05 |
| CHEMBL263720 | — | Ki | = | 10100.0 | nM | 5.00 |
| CHEMBL27830 | — | Ki | = | 15200.0 | nM | 4.82 |
| CHEMBL442107 | — | Ki | = | 15500.0 | nM | 4.81 |
| CHEMBL27595 | — | Ki | = | 19900.0 | nM | 4.70 |
| CHEMBL284186 | — | Ki | = | 21200.0 | nM | 4.67 |
| CHEMBL432263 | — | Ki | = | 25000.0 | nM | 4.60 |
| CHEMBL26849 | — | Ki | = | 43000.0 | nM | 4.37 |
| CHEMBL27050 | — | Ki | = | 52000.0 | nM | 4.28 |
| CHEMBL25962 | — | Ki | = | 87000.0 | nM | 4.06 |
| CHEMBL28065 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL283825 | — | Ki | > | 10000.0 | nM | - |