Compound Detail
CHEMBL282383
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Basic Information
| ChEMBL ID | CHEMBL282383 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YLEFFVJJULTPHH-BBWFWOEESA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
318.4
MW (Da)
3.54
ALogP
5
HBA
1
HBD
42.9
PSA (Ų)
0.68
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 7.03
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate NMDA receptor CHEMBL1907608 | Ki | 7.03 | 7.03 | 94.0 | 1 |
| Rattus norvegicus CHEMBL376 | Ki | 6.23 | 6.23 | 590.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate NMDA receptor | Ki | = | 94.0 | nM | 7.03 | Tested for the inhibition of [3H]dizocilpine binding to N-methyl-D-aspartate (NM... | 8355251 |
| Rattus norvegicus | Ki | = | 590.0 | nM | 6.23 | Displacement of [3H]TCP from PCP receptor in tissue preparation of whole rat bra... | 1349351 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8355251 | 10.1021/jm00069a008 | Glutamate NMDA receptor | 2 |
| 1349351 | 10.1021/jm00086a001 | Rattus norvegicus | 1 |
Data from ChEMBL 36 via Core Engine