Assay Detail
Binding
CHEMBL764146
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Reversible competitive inhibition of prostaglandin G/H synthase 1
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Ovis aries |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Manipulation of kinetic profiles in 2-aryl propionic acid cyclooxygenase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.55 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL563 | FLURBIPROFEN | 4.0 | 1 | 7.92 |
| CHEMBL317434 | — | — | 1 | 7.50 |
| CHEMBL161052 | — | — | 1 | 6.96 |
| CHEMBL521 | IBUPROFEN | 4.0 | 1 | 5.97 |
| CHEMBL162698 | — | — | 1 | 5.32 |
| CHEMBL350428 | — | — | 1 | 5.08 |
| CHEMBL161978 | — | — | 1 | 4.71 |
| CHEMBL161481 | — | — | 1 | 4.62 |
| CHEMBL158991 | — | — | 1 | 4.54 |
| CHEMBL350424 | — | — | 1 | 4.23 |
| CHEMBL162029 | — | — | 1 | 4.19 |
| CHEMBL159210 | — | — | 1 | - |
| CHEMBL162300 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL563 | FLURBIPROFEN | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL317434 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL161052 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL521 | IBUPROFEN | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL162698 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL350428 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL161978 | — | IC50 | = | 19500.0 | nM | 4.71 |
| CHEMBL161481 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL158991 | — | IC50 | = | 28500.0 | nM | 4.54 |
| CHEMBL350424 | — | IC50 | = | 59000.0 | nM | 4.23 |
| CHEMBL162029 | — | IC50 | = | 64500.0 | nM | 4.19 |
| CHEMBL159210 | — | IC50 | = | 215000.0 | nM | - |
| CHEMBL162300 | — | IC50 | = | 210000.0 | nM | - |