Assay Detail
Binding
CHEMBL764259
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IC50 against ovine Prostaglandin G/H synthase 1
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Ovis aries |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 1. Thiazolone and oxazolone series.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.83 | 8.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL16434 | — | — | 1 | 8.21 |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 7.91 |
| CHEMBL15904 | — | — | 1 | 7.57 |
| CHEMBL48568 | — | — | 1 | 7.02 |
| CHEMBL16251 | — | — | 1 | 6.66 |
| CHEMBL278246 | — | — | 1 | 6.34 |
| CHEMBL15781 | — | — | 1 | 5.92 |
| CHEMBL15945 | — | — | 1 | 5.89 |
| CHEMBL16550 | — | — | 1 | 5.80 |
| CHEMBL280471 | — | — | 1 | 5.46 |
| CHEMBL277515 | — | — | 1 | 5.40 |
| CHEMBL277124 | — | — | 1 | 5.14 |
| CHEMBL295739 | — | — | 1 | 4.62 |
| CHEMBL49008 | — | — | 1 | 4.38 |
| CHEMBL16855 | — | — | 1 | 4.29 |
| CHEMBL277721 | — | — | 1 | 4.28 |
| CHEMBL280226 | — | — | 1 | 4.20 |
| CHEMBL7162 | NS-398 | — | 1 | - |
| CHEMBL276506 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL16434 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL6 | INDOMETHACIN | IC50 | = | 12.2 | nM | 7.91 |
| CHEMBL15904 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL48568 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL16251 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL278246 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL15781 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL15945 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL16550 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL280471 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL277515 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL277124 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL295739 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL49008 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL16855 | — | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL277721 | — | IC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL280226 | — | IC50 | = | 63000.0 | nM | 4.20 |
| CHEMBL7162 | NS-398 | IC50 | > | 20000.0 | nM | - |
| CHEMBL276506 | — | IC50 | > | 20000.0 | nM | - |