Assay Detail
Binding
CHEMBL764260
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IC50 value against ovine Prostaglandin G/H synthase 1
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Ovis aries |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 2. 1,3,4- and 1,2,4-thiadiazole series.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 45 | 5.15 | 7.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 7.91 |
| CHEMBL275188 | — | — | 1 | 7.01 |
| CHEMBL12532 | — | — | 1 | 6.29 |
| CHEMBL279755 | — | — | 1 | 6.28 |
| CHEMBL16881 | — | — | 1 | 5.58 |
| CHEMBL16733 | — | — | 1 | 5.47 |
| CHEMBL280326 | — | — | 1 | 5.24 |
| CHEMBL274457 | — | — | 1 | 4.92 |
| CHEMBL16891 | — | — | 1 | 4.77 |
| CHEMBL16659 | — | — | 1 | 4.70 |
| CHEMBL276739 | — | — | 1 | 4.62 |
| CHEMBL17104 | — | — | 1 | 4.62 |
| CHEMBL17229 | — | — | 1 | 4.50 |
| CHEMBL274271 | — | — | 1 | 4.44 |
| CHEMBL16981 | — | — | 1 | 4.29 |
| CHEMBL279308 | — | — | 1 | 4.08 |
| CHEMBL16826 | — | — | 1 | 4.06 |
| CHEMBL279801 | — | — | 1 | 4.00 |
| CHEMBL274990 | SC-58125 | — | 1 | - |
| CHEMBL276916 | — | — | 1 | - |
| CHEMBL16854 | — | — | 1 | - |
| CHEMBL279753 | — | — | 1 | - |
| CHEMBL16522 | — | — | 1 | - |
| CHEMBL17307 | — | — | 1 | - |
| CHEMBL16647 | — | — | 1 | - |
| CHEMBL276526 | — | — | 1 | - |
| CHEMBL16698 | — | — | 1 | - |
| CHEMBL279387 | — | — | 1 | - |
| CHEMBL16977 | — | — | 1 | - |
| CHEMBL17091 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | IC50 | = | 12.2 | nM | 7.91 |
| CHEMBL275188 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL12532 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL279755 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL16881 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL16733 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL280326 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL274457 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL16891 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL16659 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL276739 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL17104 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL17229 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL274271 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL16981 | — | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL279308 | — | IC50 | = | 83000.0 | nM | 4.08 |
| CHEMBL16826 | — | IC50 | = | 88000.0 | nM | 4.06 |
| CHEMBL279801 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL416165 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL16753 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL279608 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL16814 | — | IC50 | = | - | nM | - |
| CHEMBL275838 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL276062 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL278040 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL16819 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL7162 | NS-398 | IC50 | > | 20000.0 | nM | - |
| CHEMBL16827 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL16843 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL16353 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL279336 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL16828 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL16674 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL17091 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL16977 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL279387 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL16698 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL276526 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL16647 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL17307 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL16522 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL279753 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL16854 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL276916 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL274990 | SC-58125 | IC50 | > | 20000.0 | nM | - |