Assay Detail
Binding
CHEMBL764263
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In vitro inhibitory activity against ovine Prostaglandin G/H synthase 1 (44 nM) using [14C]AA (50 uM) was determined
76
Total Activities
76
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Ovis aries |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 76 | 5.13 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 7.30 |
| CHEMBL421385 | — | — | 1 | 7.22 |
| CHEMBL96954 | — | — | 1 | 5.60 |
| CHEMBL318881 | — | — | 1 | 5.52 |
| CHEMBL96057 | — | — | 1 | 5.52 |
| CHEMBL319578 | — | — | 1 | 5.40 |
| CHEMBL318206 | — | — | 1 | 5.40 |
| CHEMBL319359 | — | — | 1 | 5.40 |
| CHEMBL317332 | — | — | 1 | 5.10 |
| CHEMBL95402 | — | — | 1 | 4.77 |
| CHEMBL97219 | — | — | 1 | 4.77 |
| CHEMBL73572 | — | — | 1 | 4.48 |
| CHEMBL329052 | — | — | 1 | 4.43 |
| CHEMBL319764 | — | — | 1 | 4.35 |
| CHEMBL319148 | — | — | 1 | 4.35 |
| CHEMBL319766 | — | — | 1 | 4.28 |
| CHEMBL97562 | — | — | 1 | 4.18 |
| CHEMBL100331 | — | — | 1 | 4.18 |
| CHEMBL97834 | — | — | 1 | - |
| CHEMBL330200 | — | — | 1 | - |
| CHEMBL97042 | — | — | 1 | - |
| CHEMBL97411 | — | — | 1 | - |
| CHEMBL97846 | — | — | 1 | - |
| CHEMBL328864 | — | — | 1 | - |
| CHEMBL329480 | — | — | 1 | - |
| CHEMBL421570 | — | — | 1 | - |
| CHEMBL95988 | — | — | 1 | - |
| CHEMBL319825 | — | — | 1 | - |
| CHEMBL97088 | — | — | 1 | - |
| CHEMBL2112399 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL421385 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL96954 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL318881 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL96057 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL319578 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL318206 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL319359 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL317332 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL95402 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL97219 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL73572 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL329052 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL319764 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL319148 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL319766 | — | IC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL100331 | — | IC50 | = | 66000.0 | nM | 4.18 |
| CHEMBL97562 | — | IC50 | = | 66000.0 | nM | 4.18 |
| CHEMBL95311 | — | IC50 | > | 66000.0 | nM | - |
| CHEMBL318410 | — | IC50 | > | 66000.0 | nM | - |
| CHEMBL95921 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL330162 | — | IC50 | > | 66000.0 | nM | - |
| CHEMBL330381 | — | IC50 | > | 66000.0 | nM | - |
| CHEMBL97179 | — | IC50 | > | 66000.0 | nM | - |
| CHEMBL95643 | — | IC50 | > | 66000.0 | nM | - |
| CHEMBL95479 | — | IC50 | > | 66000.0 | nM | - |
| CHEMBL100091 | — | IC50 | > | 66000.0 | nM | - |
| CHEMBL97130 | — | IC50 | > | 66000.0 | nM | - |
| CHEMBL319999 | — | IC50 | > | 66000.0 | nM | - |
| CHEMBL2111594 | — | IC50 | > | 66000.0 | nM | - |
| CHEMBL99199 | — | IC50 | > | 66000.0 | nM | - |
| CHEMBL99933 | — | IC50 | > | 66000.0 | nM | - |
| CHEMBL100092 | — | IC50 | > | 66000.0 | nM | - |
| CHEMBL320140 | — | IC50 | > | 66000.0 | nM | - |
| CHEMBL95052 | — | IC50 | > | 66000.0 | nM | - |
| CHEMBL95625 | — | IC50 | > | 66000.0 | nM | - |
| CHEMBL95659 | — | IC50 | > | 66000.0 | nM | - |
| CHEMBL97040 | — | IC50 | > | 66000.0 | nM | - |
| CHEMBL2112399 | — | IC50 | > | 66000.0 | nM | - |
| CHEMBL97088 | — | IC50 | > | 66000.0 | nM | - |
| CHEMBL319825 | — | IC50 | > | 66000.0 | nM | - |
| CHEMBL95988 | — | IC50 | > | 66000.0 | nM | - |
| CHEMBL421570 | — | IC50 | > | 66000.0 | nM | - |
| CHEMBL329480 | — | IC50 | > | 66000.0 | nM | - |
| CHEMBL328864 | — | IC50 | > | 66000.0 | nM | - |
| CHEMBL97846 | — | IC50 | > | 66000.0 | nM | - |
| CHEMBL97411 | — | IC50 | > | 66000.0 | nM | - |
| CHEMBL97042 | — | IC50 | > | 66000.0 | nM | - |
| CHEMBL330200 | — | IC50 | > | 66000.0 | nM | - |
| CHEMBL97834 | — | IC50 | > | 66000.0 | nM | - |