Assay Detail
Binding
CHEMBL764265
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In vitro inhibitory activity against Prostaglandin G/H synthase 1 in sheep
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Ovis aries |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Structure-based design of COX-2 selectivity into flurbiprofen.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.90 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL317434 | — | — | 1 | 8.00 |
| CHEMBL563 | FLURBIPROFEN | 4.0 | 1 | 7.96 |
| CHEMBL104009 | — | — | 1 | 7.85 |
| CHEMBL316771 | — | — | 1 | 7.20 |
| CHEMBL104592 | — | — | 1 | 7.00 |
| CHEMBL106828 | — | — | 1 | 6.72 |
| CHEMBL432782 | — | — | 1 | 5.89 |
| CHEMBL325787 | — | — | 1 | 5.85 |
| CHEMBL107938 | — | — | 1 | 5.51 |
| CHEMBL42485 | DUP-697 | — | 1 | 5.34 |
| CHEMBL106203 | — | — | 1 | 5.24 |
| CHEMBL107953 | — | — | 1 | 5.11 |
| CHEMBL106445 | — | — | 1 | 4.98 |
| CHEMBL108281 | — | — | 1 | 4.82 |
| CHEMBL104422 | — | — | 1 | 4.82 |
| CHEMBL104336 | — | — | 1 | 4.81 |
| CHEMBL104147 | — | — | 1 | 4.60 |
| CHEMBL7162 | NS-398 | — | 1 | 4.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL317434 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL563 | FLURBIPROFEN | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL104009 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL316771 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL104592 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL106828 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL432782 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL325787 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL107938 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL42485 | DUP-697 | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL106203 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL107953 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL106445 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL108281 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL104422 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL104336 | — | IC50 | = | 15500.0 | nM | 4.81 |
| CHEMBL104147 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL7162 | NS-398 | IC50 | = | 37000.0 | nM | 4.43 |