Assay Detail
Binding
CHEMBL764361
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In vitro inhibitory activity against Phosphodiesterase 4A (PDE4)
13
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
3',5'-cyclic-AMP phosphodiesterase 4A (CHEMBL254) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Substituted 2-pyridinemethanol derivatives as potent and selective phosphodiesterase-4 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 8.41 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL61191 | — | — | 4 | 9.22 |
| CHEMBL299931 | — | — | 1 | 9.10 |
| CHEMBL294717 | — | — | 1 | 9.10 |
| CHEMBL301441 | — | — | 1 | 8.92 |
| CHEMBL56971 | — | — | 1 | 8.62 |
| CHEMBL57757 | — | — | 1 | 8.52 |
| CHEMBL56575 | — | — | 1 | 8.22 |
| CHEMBL57131 | — | — | 1 | 8.22 |
| CHEMBL417776 | — | — | 1 | 7.40 |
| CHEMBL57767 | — | — | 1 | 6.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL61191 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL299931 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL294717 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL61191 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL301441 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL61191 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL56971 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL57757 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL56575 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL57131 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL417776 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL61191 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL57767 | — | IC50 | = | 102.0 | nM | 6.99 |