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Assay Detail

CHEMBL764741

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Binding
Inhibitory activity against calmodulin-dependent Phosphodiesterase was reported.
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Canis lupus familiaris
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Phosphodiesterase 1 (CHEMBL2095150)
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

Homologs of idoxifene: variation of estrogen receptor binding and calmodulin antagonism with chain length.
Hardcastle IR, Rowlands MG, Grimshaw RM, Houghton J, Jarman M.
J Med Chem (1996) 39 : 999 -1004
PubMed 8632423 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 6.13 6.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL6744 1 6.70
CHEMBL6410 1 6.70
CHEMBL267600 1 6.70
CHEMBL6718 1 6.52
CHEMBL6617 1 6.40
CHEMBL269303 1 6.30
CHEMBL6327 1 6.22
CHEMBL268389 1 6.10
CHEMBL267035 1 6.00
CHEMBL269472 1 5.96
CHEMBL6596 1 5.92
CHEMBL6318 IDOXIFENE 2.0 1 5.82
CHEMBL6547 1 5.80
CHEMBL266086 1 5.70
CHEMBL267426 1 5.66
CHEMBL6730 1 5.64

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL6744 IC50 = 200.0 nM 6.70
CHEMBL6410 IC50 = 200.0 nM 6.70
CHEMBL267600 IC50 = 200.0 nM 6.70
CHEMBL6718 IC50 = 300.0 nM 6.52
CHEMBL6617 IC50 = 400.0 nM 6.40
CHEMBL269303 IC50 = 500.0 nM 6.30
CHEMBL6327 IC50 = 600.0 nM 6.22
CHEMBL268389 IC50 = 800.0 nM 6.10
CHEMBL267035 IC50 = 1000.0 nM 6.00
CHEMBL269472 IC50 = 1100.0 nM 5.96
CHEMBL6596 IC50 = 1200.0 nM 5.92
CHEMBL6318 IDOXIFENE IC50 = 1500.0 nM 5.82
CHEMBL6547 IC50 = 1600.0 nM 5.80
CHEMBL266086 IC50 = 2000.0 nM 5.70
CHEMBL267426 IC50 = 2200.0 nM 5.66
CHEMBL6730 IC50 = 2300.0 nM 5.64