Assay Detail
Binding
CHEMBL765474
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Evaluated for its ability to inhibit PDE4A.
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
3',5'-cyclic-AMP phosphodiesterase 4A (CHEMBL254) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Quinazolines: combined type 3 and 4 phosphodiesterase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.14 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL97817 | — | — | 1 | 7.52 |
| CHEMBL98662 | — | — | 1 | 7.16 |
| CHEMBL97214 | — | — | 1 | 7.07 |
| CHEMBL420454 | — | — | 1 | 6.89 |
| CHEMBL96039 | — | — | 1 | 6.60 |
| CHEMBL97785 | — | — | 1 | 6.30 |
| CHEMBL99101 | — | — | 1 | 6.27 |
| CHEMBL318444 | — | — | 1 | 6.20 |
| CHEMBL96034 | — | — | 1 | 6.05 |
| CHEMBL418785 | — | — | 1 | 5.89 |
| CHEMBL420999 | — | — | 1 | 5.64 |
| CHEMBL97866 | — | — | 1 | 5.54 |
| CHEMBL95715 | — | — | 1 | 5.48 |
| CHEMBL98730 | — | — | 1 | 5.48 |
| CHEMBL95979 | — | — | 1 | 5.27 |
| CHEMBL431806 | — | — | 1 | 4.85 |
| CHEMBL97213 | — | — | 1 | - |
| CHEMBL99470 | — | — | 1 | - |
| CHEMBL319809 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL97817 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL98662 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL97214 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL420454 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL96039 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL97785 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL99101 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL318444 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL96034 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL418785 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL420999 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL97866 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL95715 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL98730 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL95979 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL431806 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL97213 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL99470 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL319809 | — | IC50 | > | 100000.0 | nM | - |