Assay Detail
Binding
CHEMBL765609
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Inhibition of human PTPase 1B
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Evans Blue and other dyes as protein tyrosine phosphatase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.96 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1200712 | EVANS BLUE | 4.0 | 1 | 5.89 |
| CHEMBL1640 | TRYPAN BLUE | 4.0 | 1 | 5.41 |
| CHEMBL175241 | — | — | 1 | 5.28 |
| CHEMBL425511 | CHROMOTROPATE | — | 1 | 5.01 |
| CHEMBL9470 | SHIKONIN | — | 1 | 4.60 |
| CHEMBL1366408 | CARMINE | — | 1 | 4.58 |
| CHEMBL174821 | E129 | — | 1 | 4.48 |
| CHEMBL175336 | Alizarin Red S | — | 1 | 4.40 |
| CHEMBL368082 | E126 | — | 1 | - |
| CHEMBL177880 | PAMOIC ACID | — | 1 | - |
| CHEMBL176350 | — | — | 1 | - |
| CHEMBL3144822 | — | — | 1 | - |
| CHEMBL1057 | FLUORESCEIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1200712 | EVANS BLUE | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1640 | TRYPAN BLUE | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL175241 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL425511 | CHROMOTROPATE | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL1366408 | CARMINE | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL174821 | E129 | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL175336 | Alizarin Red S | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL368082 | E126 | IC50 | = | 460000.0 | nM | - |
| CHEMBL177880 | PAMOIC ACID | IC50 | = | 310000.0 | nM | - |
| CHEMBL176350 | — | IC50 | = | 210000.0 | nM | - |
| CHEMBL3144822 | — | IC50 | = | 150000.0 | nM | - |
| CHEMBL1057 | FLUORESCEIN | IC50 | = | 600000.0 | nM | - |